{"id":"W3208337174","doi":"10.1002/wrna.1701","title":"Regulation and different functions of the animal microRNA‐induced silencing complex","year":2021,"lang":"en","type":"review","venue":"Wiley Interdisciplinary Reviews - RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Argonaute; Gene silencing; RNA-induced silencing complex; RNA interference; RNA-binding protein; Dicer; Cell biology; Biology; microRNA; RasiRNA; RNA silencing; Untranslated region; Drosha; Trans-acting siRNA; Three prime untranslated region; Messenger RNA; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214156,0.0003361669,0.0003021766,0.0004157654,0.0002775547,0.001031194,0.000311885,0.0004292034,0.00108078],"category_scores_gemma":[0.0001562275,0.000154518,0.0004000415,0.000242304,0.0004939512,0.0004483579,0.0003609235,0.0004482227,0.0008359955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008410965,"about_ca_system_score_gemma":0.0002040474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005359047,"about_ca_topic_score_gemma":0.0005021526,"domain_scores_codex":[0.9995995,0.00006281277,0.00002879428,0.0001440173,0.0001079238,0.00005685381],"domain_scores_gemma":[0.9998877,0.00001585426,0.00003146835,0.00001684844,0.00002879198,0.00001926186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007907706,0.00001850994,0.0009358231,0.0001781519,0.00003404301,0.0001331593,0.0001106311,0.0002940054,0.9766709,0.006488129,0.000436331,0.01462123],"study_design_scores_gemma":[0.00002514173,0.0002690166,0.04113017,0.00005302502,0.00007929495,0.001169699,0.0001812144,0.00779034,0.8633843,0.00286936,0.08298952,0.00005893773],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7204936,0.1352944,0.08335776,0.001350389,0.0005371241,0.0001748913,0.001297423,0.00158535,0.05590902],"genre_scores_gemma":[0.9755186,0.008328251,0.006410663,0.0003210673,0.00006024605,0.0000756119,0.0008640879,0.0001364381,0.008284982],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00108078,"threshold_uncertainty_score":0.006102622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07776220473147183,"score_gpt":0.36848430422242,"score_spread":0.2907220994909482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}