{"id":"W3208414451","doi":"10.1158/0008-5472.can-21-1079","title":"Heterogeneity of Circulating Tumor Cell–Associated Genomic Gains in Breast Cancer and Its Association with the Host Immune Response","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Sunnybrook Hospital; Sunnybrook Health Science Centre; Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"University of Toronto; Ontario Ministry of Health and Long-Term Care; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Government of Ontario; Princess Margaret Cancer Foundation","keywords":"Breast cancer; Immune system; Circulating tumor cell; Primary tumor; Breast carcinoma; Cancer; Metastatic breast cancer; Genetic heterogeneity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00221503,0.0001100465,0.0003265621,0.0001209543,0.0001334677,0.00002932091,0.00008753033,0.00006300769,0.0001645045],"category_scores_gemma":[0.000207568,0.00008193153,0.00005655858,0.0008212752,0.00007352105,0.00004874795,0.0001023931,0.0004687835,0.000002195246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001479299,"about_ca_system_score_gemma":0.001439351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002866109,"about_ca_topic_score_gemma":0.0027057,"domain_scores_codex":[0.9979218,0.000497049,0.0002410686,0.000296812,0.0006067724,0.00043651],"domain_scores_gemma":[0.9984795,0.0003491011,0.0001469175,0.0002290528,0.0006980625,0.00009739753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001199369,0.00008730707,0.1298562,0.0001442363,0.0001116833,0.0000686725,0.0007559365,0.00006241741,0.8669302,0.000003371773,0.0001405848,0.0006400159],"study_design_scores_gemma":[0.002002377,0.00006948032,0.7507449,0.0002994029,0.00005556635,0.00001775259,0.0006325555,0.00008123805,0.2455476,0.000001639504,0.0004604187,0.00008709635],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824256,0.01036088,8.578392e-7,0.006435572,0.00004917974,0.00038778,0.0001984121,0.000008059633,0.0001336053],"genre_scores_gemma":[0.9968188,0.001888146,0.00000880856,0.0001485856,0.00007357902,0.0001268016,0.00000849819,0.00002761243,0.0008992071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6213827,"threshold_uncertainty_score":0.4332719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06206170035291685,"score_gpt":0.3758840776408584,"score_spread":0.3138223772879415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}