{"id":"W3208500079","doi":"10.3390/cancers13215414","title":"Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina","keywords":"Tumor microenvironment; Cancer; Medicine; Context (archaeology); Stromal cell; Cancer research; Cancer cell; Cancer-Associated Fibroblasts; Tumor progression; Chemotherapy; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004684261,0.0008317956,0.001150109,0.001707307,0.0002098499,0.0009162155,0.0007309821,0.001064687,0.002192551],"category_scores_gemma":[0.0003584787,0.000216346,0.0004138109,0.001378525,0.0004770876,0.001291236,0.0005712844,0.002006928,0.001198273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006955038,"about_ca_system_score_gemma":0.0006245589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005379302,"about_ca_topic_score_gemma":0.001206143,"domain_scores_codex":[0.9998513,0.00003397478,0.00001534834,0.00002647856,0.00005641089,0.00001648318],"domain_scores_gemma":[0.9998693,0.00006538731,0.0000160869,0.000005010013,0.00003122971,0.00001297653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008883057,0.0001260162,0.0001363724,0.01424455,0.00009706367,0.0002413288,0.00007861595,0.0005767323,0.004697266,0.01149129,0.02919103,0.939031],"study_design_scores_gemma":[0.00001799591,0.0001225334,0.0004719994,0.001952925,0.00006221684,0.001255819,0.00003418582,0.0001387715,0.0007057362,0.002258803,0.9929652,0.00001373285],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001355773,0.9981852,0.000178304,0.0002446548,0.0001932784,0.000005765238,0.000009219986,0.000006204066,0.0010418],"genre_scores_gemma":[0.0009537276,0.9974746,0.0002685727,0.0002564776,0.0001474496,0.00001211614,0.00002227531,0.000001721766,0.0008630549],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002192551,"threshold_uncertainty_score":0.007334828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04676752615553993,"score_gpt":0.3314388625690999,"score_spread":0.28467133641356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}