{"id":"W3208500079","doi":"10.3390/cancers13215414","title":"Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina","keywords":"Tumor microenvironment; Cancer; Medicine; Context (archaeology); Stromal cell; Cancer research; Cancer cell; Cancer-Associated Fibroblasts; Tumor progression; Chemotherapy; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000226988,0.0006915642,0.002377979,0.00006840043,0.0001250452,0.00005845126,0.0003667472,0.00016688,0.00297387],"category_scores_gemma":[0.000009532094,0.000420326,0.001247085,0.0002912895,0.0002182803,0.00004178228,0.00007505289,0.0005978217,0.00006164049],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005340687,"about_ca_system_score_gemma":0.002684091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001626858,"about_ca_topic_score_gemma":0.00003327368,"domain_scores_codex":[0.9974712,0.0001733539,0.000582649,0.0008309292,0.0003838915,0.0005579772],"domain_scores_gemma":[0.998254,0.00009727215,0.0004807892,0.0009287791,0.00003239683,0.0002067548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005162041,0.00005456748,0.00001297586,0.001035968,0.001578144,0.00001535889,0.00005951105,0.000008607504,0.0002918848,0.00000172764,0.03760642,0.9592832],"study_design_scores_gemma":[0.001825872,0.0001019039,0.000009353689,0.002536307,0.0009227683,0.00003004225,0.00007796309,0.000004413883,0.0009454897,2.648057e-7,0.993131,0.0004146645],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001021239,0.9948554,0.00001277638,0.0002402826,0.0008305047,0.001875806,0.0007818519,0.00003283102,0.0003493089],"genre_scores_gemma":[0.00006290116,0.9910864,0.00008659978,0.001851953,0.0006889722,0.001069925,0.000252105,0.000169411,0.004731738],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9588686,"threshold_uncertainty_score":0.9998249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04676752615553993,"score_gpt":0.3314388625690999,"score_spread":0.28467133641356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}