{"id":"W3208539766","doi":"10.1016/j.celrep.2021.109909","title":"Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Epigenomics; Biology; Genetics; Induced pluripotent stem cell; Germline; Retrotransposon; DNA methylation; Embryonic stem cell; Genome; Gene; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009212065,0.0001051944,0.0001072127,0.0002665897,0.0001156503,0.0002439884,0.0001076556,0.0001037632,0.0005265109],"category_scores_gemma":[0.0001819187,0.00009122611,0.00009962993,0.000191485,0.0001904222,0.0001335295,0.0002449004,0.0001535072,0.0001114637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001016114,"about_ca_system_score_gemma":0.00009515132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000294037,"about_ca_topic_score_gemma":0.0006317779,"domain_scores_codex":[0.9998989,0.00001240751,0.000009636748,0.00003197395,0.00003370421,0.00001325959],"domain_scores_gemma":[0.9998738,0.00002771004,0.00004922618,0.00001684033,0.00001627548,0.00001611667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003478792,0.00000278373,0.005117584,0.00002339978,0.00001037415,0.00006350621,0.00003148664,0.00009374366,0.9915054,0.0001426773,0.00001240966,0.002961764],"study_design_scores_gemma":[0.000006739303,0.0001427336,0.2856631,0.000009447948,0.00007111151,0.002097971,0.0001279157,0.001036877,0.7076434,0.0005958002,0.002591523,0.00001343033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990763,0.0008746224,0.007129663,0.00003193953,0.000003729822,0.000008987983,0.0003246251,0.00004381658,0.0008195278],"genre_scores_gemma":[0.9985029,0.0001895955,0.00074465,0.0000142664,0.00000251913,0.000005634638,0.0002465654,0.000006784716,0.0002871959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005265109,"threshold_uncertainty_score":0.001761377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02659924416745934,"score_gpt":0.2645176665325901,"score_spread":0.2379184223651308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}