{"id":"W3208616104","doi":"10.1128/jb.00297-21","title":"Putrescine and Its Metabolic Precursor Arginine Promote Biofilm and c-di-GMP Synthesis in Pseudomonas aeruginosa","year":2021,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Biofilm; Pseudomonas aeruginosa; Biology; Microbiology; Bacteria; Antimicrobial; Immune system; Arginine; Putrescine; Biochemistry; Immunology; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003227501,0.0001809745,0.0004843947,0.0001092134,0.00004016295,0.00003348269,0.00008440617,0.0002237083,0.00002801111],"category_scores_gemma":[0.0003337048,0.0001516672,0.00007377758,0.00009826187,0.00008423519,0.00001473059,0.0001315211,0.0001745102,0.000001412753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007201371,"about_ca_system_score_gemma":0.0001044407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006443765,"about_ca_topic_score_gemma":0.00003247444,"domain_scores_codex":[0.9987603,0.000190978,0.0004464437,0.0002778753,0.00006393332,0.0002604678],"domain_scores_gemma":[0.9992838,0.00004034774,0.0002587254,0.0001443628,0.0001461302,0.0001266575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002354608,0.00005429376,0.003878497,0.00002405225,0.00008321904,0.00011079,0.00004568084,0.000001265384,0.9882153,0.00005359999,0.00004501317,0.007252811],"study_design_scores_gemma":[0.001030771,0.0004177305,0.09867527,0.00008312854,0.0000669338,0.00283348,0.00004500058,0.00002487856,0.8762996,0.00002026514,0.02029855,0.0002043825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909868,0.007186652,0.000006645185,0.001354682,0.0003007579,0.00007742357,0.00001861574,0.000002849938,0.00006553798],"genre_scores_gemma":[0.9935801,0.004526161,0.001236358,0.0001620646,0.0003763729,0.000002132803,0.00001269035,0.00001708664,0.00008702234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1119157,"threshold_uncertainty_score":0.618481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009879152649896025,"score_gpt":0.2339202002760504,"score_spread":0.2240410476261544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}