{"id":"W3208635967","doi":"10.1016/j.htct.2021.10.331","title":"EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135), A B-CELL MATURATION ANTIGEN (BCMA)-CD3 BISPECIFIC ANTIBODY, IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA","year":2021,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Institute of Cancer Research; McGill University Health Centre; University of Calgary","funders":"","keywords":"Medicine; Cytokine release syndrome; Common Terminology Criteria for Adverse Events; Adverse effect; Multiple myeloma; Neutropenia; Internal medicine; Gastroenterology; Oncology; Toxicity; Chimeric antigen receptor; Immunology; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002485062,0.000283957,0.0007473549,0.0002607773,0.0001194651,0.00001812701,0.00008543296,0.0002955926,0.001561899],"category_scores_gemma":[0.00002141685,0.0002062518,0.00007344098,0.0004798058,0.0002391475,0.00009828986,0.00002424548,0.0004269097,0.000004847299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003315217,"about_ca_system_score_gemma":0.0001689859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004807178,"about_ca_topic_score_gemma":0.000137038,"domain_scores_codex":[0.9978884,0.0002584759,0.0005317077,0.0005846795,0.0003758429,0.0003608191],"domain_scores_gemma":[0.9987804,0.0003211528,0.0001159072,0.0004265922,0.0001961272,0.0001598738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.06755427,0.003026935,0.2533213,0.0004469851,0.0001030239,0.0002763754,0.002462481,0.000001573622,0.6406865,0.00004134764,0.00007163975,0.03200767],"study_design_scores_gemma":[0.078011,0.002994853,0.5965225,0.000382405,0.00004344042,0.0001731389,0.0008103923,0.0001332101,0.3110132,0.00001744095,0.00950253,0.0003959662],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938273,0.003468246,0.0001552612,0.0003411021,0.00007759455,0.00117607,0.00001609686,0.00003618925,0.0009020814],"genre_scores_gemma":[0.9652419,0.03303289,0.0004978055,0.0001584358,0.0000190631,0.00001587386,0.0001731777,0.00005123325,0.0008096336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3432012,"threshold_uncertainty_score":0.9993508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486742412468083,"score_gpt":0.2713815356584001,"score_spread":0.2565141115337193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}