{"id":"W3208644800","doi":"10.26434/chemrxiv.11556144.v1","title":"A CycloRGDf(Me-V) Analog as Chemical Probe to Study Integrins Function in Living Cells","year":2020,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Integrin; Flow cytometry; Confocal; Cell biology; Dissociation constant; Chemistry; Fluorescence; Confocal microscopy; Biophysics; Cell; Nanotechnology; Molecular biology; Biochemistry; Biology; Receptor; Materials science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549614,0.0003135572,0.0001791395,0.0001497798,0.0001343283,0.0002299729,0.000307551,0.0005188109,0.00177696],"category_scores_gemma":[0.0001076263,0.0001292599,0.0001638255,0.0001452749,0.0002049049,0.0002300373,0.0001529839,0.0005129249,0.000417355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003789297,"about_ca_system_score_gemma":0.0001391451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005582809,"about_ca_topic_score_gemma":0.0005498562,"domain_scores_codex":[0.9998835,0.00001657661,0.000003719267,0.00004366284,0.00002550027,0.00002701157],"domain_scores_gemma":[0.9999458,0.00002075346,0.00001216098,0.000007085035,0.000005510815,0.000008780679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001828499,0.000008938146,0.00004030623,0.00002813048,0.000001954304,0.00003735322,0.000007315006,0.00005542762,0.9981553,0.0002939118,0.0000931609,0.001259957],"study_design_scores_gemma":[0.000008174622,0.00007708775,0.000332916,0.000002744262,0.000003530417,0.0001837855,0.000004737059,0.0003391861,0.9950662,0.00003615322,0.003942576,0.000002881741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8961044,0.009374547,0.07514863,0.001208558,0.0002070878,0.0001698063,0.0006662156,0.0004006787,0.01672],"genre_scores_gemma":[0.9528567,0.00280627,0.03513052,0.0003489155,0.00005675388,0.0001483082,0.0004900284,0.0000761337,0.008086379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177696,"threshold_uncertainty_score":0.00594455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03963961003091433,"score_gpt":0.3266988635292013,"score_spread":0.287059253498287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}