{"id":"W3208672684","doi":"10.1038/s41582-021-00581-x","title":"Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis","year":2021,"lang":"en","type":"review","venue":"Nature Reviews Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Fingolimod; Neuroprotection; Neuropathology; Multiple sclerosis; Remyelination; Natalizumab; Disease; Mechanism (biology); Neuroscience; Drug repositioning; Drug; Bioinformatics; Pharmacology; Immunology; Internal medicine; Myelin; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004123121,0.001162778,0.00443322,0.002580911,0.0002549874,0.001390969,0.001674951,0.001545833,0.005453915],"category_scores_gemma":[0.006955462,0.0002750483,0.002616288,0.00167143,0.0007456605,0.00125743,0.0009364581,0.001897631,0.0006893385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001053282,"about_ca_system_score_gemma":0.001927675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00137078,"about_ca_topic_score_gemma":0.003304294,"domain_scores_codex":[0.9985896,0.0004707392,0.0004634437,0.0001294696,0.0002952271,0.00005158241],"domain_scores_gemma":[0.9971187,0.002133704,0.0004308224,0.00005517135,0.0002182248,0.00004345275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008651805,0.0001507437,0.0005155584,0.1919536,0.00378223,0.0001465529,0.00006614597,0.0003814826,0.000785355,0.005649497,0.01428913,0.7814146],"study_design_scores_gemma":[0.004748685,0.00170632,0.01004093,0.2927712,0.03063615,0.001787893,0.0002348216,0.000691668,0.001700575,0.01784805,0.6376589,0.0001747976],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001346354,0.9988501,0.0001190733,0.0002903446,0.0001649881,0.00003564057,0.00003521279,0.000004847591,0.0003651607],"genre_scores_gemma":[0.003041883,0.9948548,0.0007931812,0.0007403338,0.0002193692,0.00007460787,0.00007463741,0.000002382309,0.0001987522],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005453915,"threshold_uncertainty_score":0.02180541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1425144545932931,"score_gpt":0.4332337085251379,"score_spread":0.2907192539318447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}