{"id":"W3208690493","doi":"10.1161/jaha.120.020451","title":"SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes","year":2021,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"SIRT3; Medicine; Insulin resistance; Internal medicine; Pulmonary artery; Single-nucleotide polymorphism; Endocrinology; Mitochondrion; Pulmonary hypertension; Type 2 diabetes; Diabetes mellitus; Cardiology; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002772318,0.0005945703,0.0002733193,0.0007445737,0.00020694,0.0002931425,0.0002175171,0.0003932729,0.001765609],"category_scores_gemma":[0.0003436251,0.0002363212,0.0004364969,0.000337276,0.0002333175,0.0001474125,0.0002771861,0.0005316939,0.0001492397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098264,"about_ca_system_score_gemma":0.0001173563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004424913,"about_ca_topic_score_gemma":0.0007197031,"domain_scores_codex":[0.9997445,0.00004908537,0.0000363065,0.00009964537,0.00004637326,0.0000241085],"domain_scores_gemma":[0.9996153,0.0000488656,0.0001804824,0.00005022145,0.00001698586,0.00008803495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00463549,0.0005129055,0.2511759,0.00009459764,0.0005402519,0.0011278,0.00016369,0.0003408008,0.7337389,0.0002367874,0.0002571877,0.007175563],"study_design_scores_gemma":[0.0001987945,0.00132083,0.9486176,0.00002616429,0.0004919696,0.007875937,0.00009644606,0.001825879,0.03830185,0.000201859,0.001021389,0.0000212989],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984281,0.0001156813,0.0009697591,0.00004050907,0.000009349226,0.000008088404,0.0002784417,0.00001788622,0.0001320629],"genre_scores_gemma":[0.9980465,0.00009777291,0.0009607642,0.00003796855,0.00001194766,0.0000234762,0.0004185267,0.000008482058,0.0003944898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765609,"threshold_uncertainty_score":0.005906522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881105918905298,"score_gpt":0.2514356685334441,"score_spread":0.2326246093443911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}