{"id":"W3208700567","doi":"10.3389/fonc.2021.745981","title":"Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Cisplatin; Clonogenic assay; Poly ADP ribose polymerase; Apoptosis; Cancer research; Cell cycle; Flow cytometry; Programmed cell death; Gene knockdown; Chemistry; Biology; Molecular biology; Polymerase; Chemotherapy; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003644703,0.000401848,0.001080502,0.0006785484,0.0001063879,0.00002240807,0.00009543924,0.0004818338,0.0004098053],"category_scores_gemma":[0.00014358,0.0004428718,0.0001574902,0.000869912,0.0003179429,0.0001747531,0.0001402216,0.0004955204,0.00001798892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009647223,"about_ca_system_score_gemma":0.001044257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007561864,"about_ca_topic_score_gemma":0.0002546031,"domain_scores_codex":[0.9968161,0.0003644298,0.0009180252,0.0007918642,0.00043735,0.0006722487],"domain_scores_gemma":[0.9982896,0.0001463587,0.0003428975,0.0004873498,0.0002294364,0.0005043297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004997608,0.001065807,0.02371847,0.0002699381,0.0003767902,0.002900688,0.005385783,0.00008563649,0.7288917,0.00006553443,0.1533322,0.07890981],"study_design_scores_gemma":[0.0135961,0.001167844,0.005647044,0.0007283287,0.0002029136,0.0002844266,0.001771178,0.0004848232,0.9301557,0.000342652,0.04505574,0.0005632463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713832,0.007014864,0.001533173,0.01167176,0.005131899,0.0008991861,0.0004572981,0.00008607167,0.001822544],"genre_scores_gemma":[0.973959,0.00079323,0.01452264,0.007748624,0.001442753,0.0001705997,0.0001593765,0.00009194315,0.001111881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.201264,"threshold_uncertainty_score":0.9998023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562251702974704,"score_gpt":0.3059885350703799,"score_spread":0.2903660180406328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}