{"id":"W3208700567","doi":"10.3389/fonc.2021.745981","title":"Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Cisplatin; Clonogenic assay; Poly ADP ribose polymerase; Apoptosis; Cancer research; Cell cycle; Flow cytometry; Programmed cell death; Gene knockdown; Chemistry; Biology; Molecular biology; Polymerase; Chemotherapy; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008486832,0.0002052459,0.0002573679,0.0002304116,0.00007632603,0.0002571768,0.0001231819,0.0001466335,0.001012189],"category_scores_gemma":[0.0001176909,0.0001016075,0.0002110999,0.0002215078,0.0001013153,0.0001221617,0.0001143956,0.0003399746,0.0002620953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002778929,"about_ca_system_score_gemma":0.0001653367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007679625,"about_ca_topic_score_gemma":0.001514734,"domain_scores_codex":[0.9999019,0.00001170843,0.000009547112,0.00002316419,0.00003222812,0.00002145709],"domain_scores_gemma":[0.9999366,0.00001247794,0.00001966484,0.000009143065,0.00001145675,0.00001071574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003222584,0.00008979671,0.00245448,0.0001644651,0.00004463675,0.00009042653,0.00002145919,0.0003264472,0.9826078,0.00005155307,0.0002893536,0.01353739],"study_design_scores_gemma":[0.00003515119,0.001101851,0.02215892,0.00001001671,0.00004755429,0.0004255357,0.0000231515,0.001209631,0.9681557,0.00002555765,0.006802578,0.000004375422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872782,0.007972399,0.001880378,0.0001148851,0.00003679382,0.00006272337,0.0004931402,0.0001235644,0.00203782],"genre_scores_gemma":[0.9931843,0.003197523,0.001545235,0.00005299917,0.00001071313,0.00004036993,0.0007530766,0.00001405186,0.001201882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001012189,"threshold_uncertainty_score":0.00338608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562251702974704,"score_gpt":0.3059885350703799,"score_spread":0.2903660180406328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}