{"id":"W3208714907","doi":"10.1128/mbio.02062-21","title":"Modulation of the Host Cell Transcriptome and Epigenome by Fusobacterium nucleatum","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; University of Guelph; Simon Fraser University","funders":"Canadian Institutes of Health Research; Cancer Research UK; Government of Canada","keywords":"Fusobacterium nucleatum; Epigenome; Transcriptome; Host (biology); Computational biology; Metagenomics; Microbiome; Biology; Computer science; Microbiology; Bacteria; Bioinformatics; Genetics; Gene; Gene expression; DNA methylation; Porphyromonas gingivalis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195059,0.0001886763,0.0003577941,0.0002741683,0.0001920364,0.0003843755,0.00007124277,0.0002805197,0.0007762464],"category_scores_gemma":[0.0002066754,0.00009271031,0.0001878333,0.0002823297,0.0001657797,0.0002236568,0.000290583,0.0002662707,0.0001936709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001677348,"about_ca_system_score_gemma":0.0001307598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009540052,"about_ca_topic_score_gemma":0.00107011,"domain_scores_codex":[0.9998546,0.00002346621,0.000005923221,0.00004700994,0.00002764969,0.00004137226],"domain_scores_gemma":[0.9999168,0.00002078494,0.00002378428,0.000006569365,0.00001695284,0.00001511665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000252038,0.00001258552,0.005510006,0.00006520062,0.00001414399,0.00006378598,0.00008062788,0.00007578031,0.9905832,0.00003806159,0.00007614341,0.003228473],"study_design_scores_gemma":[0.00001885521,0.0007050834,0.7095067,0.00007993036,0.0001217719,0.0005732853,0.001349393,0.002869237,0.2762872,0.0005479623,0.007897361,0.00004324484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928965,0.002547082,0.001864436,0.000101925,0.00002995296,0.00001735746,0.001608514,0.00003629182,0.0008979105],"genre_scores_gemma":[0.9958439,0.0009510612,0.001106853,0.0001163235,0.00001641074,0.00003652007,0.001140745,0.00001029224,0.0007777596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009540052,"threshold_uncertainty_score":0.002596855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00395488782894897,"score_gpt":0.1942261698506579,"score_spread":0.1902712820217089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}