{"id":"W3208792236","doi":"10.3389/fmicb.2021.764733","title":"Broad-Spectrum Inhibitor of Bacterial Polyphosphate Homeostasis Attenuates Virulence Factors and Helps Reveal Novel Physiology of Klebsiella pneumoniae and Acinetobacter baumannii","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Universidad de Chile; Beijing Normal University; Cystic Fibrosis Canada","keywords":"Acinetobacter baumannii; Virulence; Microbiology; Biology; Klebsiella pneumoniae; Biofilm; Pseudomonas aeruginosa; Acinetobacter; Human pathogen; Antibiotics; Pyocyanin; Microbiome; Quorum sensing; Multidrug tolerance; Bacteria; Escherichia coli; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160159,0.0003474097,0.0002764635,0.0001911601,0.0001051289,0.0002324802,0.0001542317,0.0002777925,0.0009508305],"category_scores_gemma":[0.00009482018,0.0000978899,0.0002215082,0.00009111883,0.000185482,0.0002308894,0.0002211307,0.0006857946,0.0001831138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001476786,"about_ca_system_score_gemma":0.0002106333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003949235,"about_ca_topic_score_gemma":0.0008029355,"domain_scores_codex":[0.9998931,0.00001695856,0.00001122442,0.00002186158,0.00003056873,0.00002643975],"domain_scores_gemma":[0.9999504,0.000005898381,0.00001308062,0.000006838523,0.000008089997,0.00001563513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001610405,0.00003321094,0.00009663097,0.00007031045,0.000004120844,0.0000234608,0.000008485472,0.00004387947,0.9976448,0.00004710383,0.00005364687,0.001813224],"study_design_scores_gemma":[0.00002072545,0.001333716,0.004774959,0.00001506687,0.00002518793,0.0002387277,0.00004099602,0.0006112789,0.9879765,0.0000703253,0.004886021,0.000006493048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822689,0.009638159,0.004117619,0.0005022899,0.0001019704,0.00005167068,0.0005449905,0.0001662688,0.00260807],"genre_scores_gemma":[0.9898499,0.004379401,0.002499512,0.0001801424,0.00002103381,0.00003643614,0.0004079579,0.00001835552,0.002607138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009508305,"threshold_uncertainty_score":0.003180861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009758683208511466,"score_gpt":0.2221182746022951,"score_spread":0.2123595913937836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}