{"id":"W3208801862","doi":"10.1016/j.stem.2021.10.004","title":"Enteric glial cell heterogeneity regulates intestinal stem cell niches","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Congenital gastrointestinal and neural anomalies","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Terry Fox Research Institute; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Biology; LGR5; Stem cell; Cell biology; Enteric nervous system; Glial fibrillary acidic protein; Wnt signaling pathway; Regeneration (biology); Adult stem cell; Immunology; Stem cell marker; Intestinal mucosa; Paneth cell; Cellular differentiation; Small intestine; Neuroscience; Cancer stem cell; Signal transduction; Genetics; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453011,0.0001522894,0.0002043654,0.0004235965,0.0003011499,0.0008156621,0.0002706954,0.0002324549,0.001023711],"category_scores_gemma":[0.0002807825,0.000152209,0.0001254085,0.0002052719,0.0003967803,0.0004156467,0.0004808073,0.0004730837,0.0001542249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004506239,"about_ca_system_score_gemma":0.0002403512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008976493,"about_ca_topic_score_gemma":0.002371196,"domain_scores_codex":[0.9997773,0.00003205998,0.00001149388,0.00004419411,0.00005460868,0.00008046124],"domain_scores_gemma":[0.9997738,0.000043105,0.00005187024,0.00001889663,0.00003203982,0.00008025917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003171103,0.00001777921,0.003043699,0.00002651971,0.000008878977,0.0001943182,0.0001113149,0.0001177177,0.9924814,0.001542475,0.00008505722,0.002053759],"study_design_scores_gemma":[0.00006803882,0.0002795389,0.09887665,0.00001994066,0.00007035879,0.0009789573,0.001375232,0.00409736,0.8869606,0.001194327,0.006058674,0.00002043824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974381,0.0004381199,0.0008521069,0.00004940478,0.000008910887,0.00000290448,0.00004676707,0.00001906072,0.001144618],"genre_scores_gemma":[0.9990484,0.0001219964,0.0003068552,0.00001497167,0.000005894353,0.000003765664,0.00005297466,0.00001611843,0.0004291183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023711,"threshold_uncertainty_score":0.003424644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02425065182601328,"score_gpt":0.2253899159942627,"score_spread":0.2011392641682495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}