{"id":"W3208801862","doi":"10.1016/j.stem.2021.10.004","title":"Enteric glial cell heterogeneity regulates intestinal stem cell niches","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Congenital gastrointestinal and neural anomalies","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Terry Fox Research Institute; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Biology; LGR5; Stem cell; Cell biology; Enteric nervous system; Glial fibrillary acidic protein; Wnt signaling pathway; Regeneration (biology); Adult stem cell; Immunology; Stem cell marker; Intestinal mucosa; Paneth cell; Cellular differentiation; Small intestine; Neuroscience; Cancer stem cell; Signal transduction; Genetics; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000151123,0.0005860018,0.000708902,0.0001068451,0.0001813984,0.0001119909,0.0003024121,0.0001473752,0.0004408357],"category_scores_gemma":[0.000007682659,0.0005126395,0.0004673351,0.0003751095,0.0001574246,0.0001342803,0.000413365,0.0004854687,0.0007200484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001151345,"about_ca_system_score_gemma":0.0001834793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003159284,"about_ca_topic_score_gemma":0.00002597642,"domain_scores_codex":[0.9969572,0.0001579807,0.0007020058,0.0009335038,0.0004630188,0.000786287],"domain_scores_gemma":[0.9980464,0.0002033412,0.0002620375,0.0006775068,0.000295712,0.0005150125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003803674,0.0009715959,0.0271133,0.001379468,0.00002022579,0.001663706,0.000259729,0.00001422245,0.9629328,0.000002858355,0.001494985,0.003766699],"study_design_scores_gemma":[0.001721793,0.001141499,0.004370248,0.000173428,0.0002244902,0.0008875568,0.000808409,0.0002418765,0.9825138,0.00001234632,0.007434297,0.0004702176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657336,0.004198722,0.00005778624,0.0002318873,0.0004889838,0.0003807813,0.00003094214,0.0002043401,0.02867293],"genre_scores_gemma":[0.8927784,0.00009759877,0.0007512118,0.0003150346,0.0003165395,0.00002179387,0.00005052163,0.00007280926,0.1055961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07692317,"threshold_uncertainty_score":0.9997325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02425065182601328,"score_gpt":0.2253899159942627,"score_spread":0.2011392641682495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}