{"id":"W3208814858","doi":"10.1182/blood-2021-148039","title":"Primary Analysis of ZUMA-7: A Phase 3 Randomized Trial of Axicabtagene Ciloleucel (Axi-Cel) Versus Standard-of-Care Therapy in Patients with Relapsed/Refractory Large B-Cell Lymphoma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Medicine; Refractory (planetary science); Internal medicine; Oncology; Lymphoma; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008832052,0.000254478,0.002248478,0.0006462343,0.00002917576,0.000008435667,0.0001756467,0.0001713677,0.001038098],"category_scores_gemma":[0.0002634057,0.0002003044,0.0007166506,0.001556077,0.0001855528,0.00006292709,0.00006689523,0.0001946655,0.000001071748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527952,"about_ca_system_score_gemma":0.001022803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005017087,"about_ca_topic_score_gemma":0.00004672341,"domain_scores_codex":[0.9964548,0.000544812,0.0009328165,0.0004249713,0.001294819,0.0003478014],"domain_scores_gemma":[0.9970913,0.0006221112,0.000458805,0.0008346754,0.0008591394,0.0001340033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9223468,0.02778319,0.004142367,0.000244383,0.004853983,0.00006534527,0.001204886,0.000003617186,0.02936313,0.000006951517,0.00001298607,0.009972388],"study_design_scores_gemma":[0.851414,0.01231182,0.001605037,0.00009703243,0.002451168,4.650818e-7,0.0002633479,0.00001353935,0.1313687,0.000002614648,0.0003262276,0.0001460677],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919478,0.003030006,0.00002800057,0.00001731875,0.0001069574,0.001646233,0.0003476881,0.00001544945,0.002860602],"genre_scores_gemma":[0.9975423,0.001096432,0.0003407207,0.00002689607,0.00004554066,0.00006131666,0.0005459542,0.00004642429,0.0002944827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1020055,"threshold_uncertainty_score":0.9998751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574669510449311,"score_gpt":0.293887349007926,"score_spread":0.2781406539034329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}