{"id":"W3208814858","doi":"10.1182/blood-2021-148039","title":"Primary Analysis of ZUMA-7: A Phase 3 Randomized Trial of Axicabtagene Ciloleucel (Axi-Cel) Versus Standard-of-Care Therapy in Patients with Relapsed/Refractory Large B-Cell Lymphoma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Medicine; Refractory (planetary science); Internal medicine; Oncology; Lymphoma; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003187075,0.002188455,0.002482696,0.0004315457,0.0005332281,0.001394514,0.001061204,0.001523652,0.01054406],"category_scores_gemma":[0.001866128,0.000635561,0.003175463,0.000409297,0.001107465,0.000964685,0.0006331704,0.003646781,0.001596884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001113011,"about_ca_system_score_gemma":0.001709576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009614167,"about_ca_topic_score_gemma":0.002416565,"domain_scores_codex":[0.998989,0.0006179578,0.00003756583,0.0001520919,0.00006257811,0.0001408738],"domain_scores_gemma":[0.9989662,0.0002603595,0.0002271847,0.00008013975,0.00008595601,0.0003801095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9790437,0.004777347,0.0009514389,0.0006865271,0.002023358,0.00005053651,0.00003804796,0.0004504932,0.002143375,0.0001372749,0.001743719,0.007954111],"study_design_scores_gemma":[0.9411035,0.05262919,0.002395016,0.00004149245,0.001331125,0.00005218284,0.00002994658,0.000685177,0.0004236381,0.00032728,0.0009665798,0.00001486987],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631447,0.007345107,0.00174002,0.001671152,0.0007911478,0.01317176,0.005942485,0.0003708608,0.005822664],"genre_scores_gemma":[0.9746997,0.001897956,0.002052059,0.00186479,0.0004514644,0.01109796,0.00359306,0.00007455739,0.004268515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01054406,"threshold_uncertainty_score":0.03527337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574669510449311,"score_gpt":0.293887349007926,"score_spread":0.2781406539034329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}