{"id":"W3208882535","doi":"10.1039/d1em00307k","title":"Emerging investigator series: human CYP2A6 catalyzes the oxidation of 6:2 fluorotelomer alcohol","year":2021,"lang":"en","type":"article","venue":"Environmental Science Processes & Impacts","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CYP2A6; Chemistry; Microsome; Biotransformation; Cytochrome P450; Enzyme; Metabolism; Biochemistry; CYP3A4","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004077073,0.00134397,0.0005579117,0.001236223,0.00100004,0.001847564,0.001811607,0.003966633,0.0707037],"category_scores_gemma":[0.001381886,0.0002842628,0.0008633442,0.001080767,0.0005113152,0.001755274,0.001008921,0.002063021,0.02283042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001319776,"about_ca_system_score_gemma":0.003521306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048876,"about_ca_topic_score_gemma":0.002051676,"domain_scores_codex":[0.9988734,0.000115357,0.00008508348,0.0002800511,0.0003870142,0.0002590509],"domain_scores_gemma":[0.9976249,0.0001626032,0.0002244446,0.0001195591,0.000947696,0.0009208135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002519045,0.002747312,0.01175448,0.001704745,0.0001197432,0.001534547,0.0001908265,0.0003992561,0.07275834,0.008290722,0.4070456,0.4909354],"study_design_scores_gemma":[0.0006143643,0.006340973,0.01534339,0.0002750614,0.0001673969,0.002581721,0.0003716182,0.0006161363,0.08484218,0.003237428,0.8855656,0.00004409049],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.1130405,0.08528697,0.01899843,0.1217644,0.08782188,0.006525311,0.01929818,0.001944447,0.54532],"genre_scores_gemma":[0.2088521,0.07964484,0.009279834,0.01066681,0.06240321,0.001109102,0.03266518,0.0002404931,0.5951384],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0707037,"threshold_uncertainty_score":0.2365274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672682764679732,"score_gpt":0.2861005337292188,"score_spread":0.2693737060824215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}