{"id":"W3208894493","doi":"10.1016/j.ekir.2021.10.017","title":"Efficacy of Rituximab in Treatment-Resistant Focal Segmental Glomerulosclerosis With Elevated Soluble Urokinase-Type Plasminogen Activator Receptor and Activation of Podocyte β3 Integrin","year":2021,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"SuPAR; Medicine; Rituximab; Focal segmental glomerulosclerosis; Proteinuria; Renal function; Internal medicine; Podocyte; Nephrotic syndrome; Plasminogen activator; Gastroenterology; Urology; Immunology; Kidney; Urokinase receptor; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008829672,0.0001778955,0.000395606,0.0001830943,0.00002559575,0.00001650932,0.0000405305,0.00007162982,0.0002653373],"category_scores_gemma":[0.0006863856,0.000141579,0.00009426867,0.000291116,0.00008974596,0.0001504817,0.0000454714,0.00009382256,0.000001713909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002645569,"about_ca_system_score_gemma":0.0005760648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004201358,"about_ca_topic_score_gemma":0.00002153572,"domain_scores_codex":[0.9984557,0.0000359431,0.0005436823,0.0003417103,0.0004676902,0.0001552522],"domain_scores_gemma":[0.9988153,0.00007969177,0.0003554085,0.0002127089,0.0003399675,0.0001969184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00692545,0.003010065,0.159475,0.0001981599,0.0006913172,0.0005235138,0.0002961438,0.00001206027,0.8247744,0.0001366691,0.0006677604,0.003289444],"study_design_scores_gemma":[0.005838098,0.0008227979,0.2459749,0.001088509,0.000131061,0.0001780241,0.0002927451,0.0000921192,0.7429051,0.00003348423,0.002496601,0.0001465782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979795,0.0001414737,0.00001678456,0.000619995,0.0001859989,0.0002675375,0.00007838556,0.0000161867,0.0006941266],"genre_scores_gemma":[0.9978511,0.0002329093,0.0006868364,0.00008385342,0.00004470901,0.00001776937,0.0005641145,0.00002025852,0.0004984266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08649988,"threshold_uncertainty_score":0.5773424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152818257891278,"score_gpt":0.2664392740389409,"score_spread":0.2511574482498131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}