{"id":"W3208894493","doi":"10.1016/j.ekir.2021.10.017","title":"Efficacy of Rituximab in Treatment-Resistant Focal Segmental Glomerulosclerosis With Elevated Soluble Urokinase-Type Plasminogen Activator Receptor and Activation of Podocyte β3 Integrin","year":2021,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"SuPAR; Medicine; Rituximab; Focal segmental glomerulosclerosis; Proteinuria; Renal function; Internal medicine; Podocyte; Nephrotic syndrome; Plasminogen activator; Gastroenterology; Urology; Immunology; Kidney; Urokinase receptor; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00185838,0.000522182,0.001262984,0.000258107,0.0001768475,0.0003725052,0.0004375967,0.0007199685,0.0008292699],"category_scores_gemma":[0.001765977,0.0001989954,0.0005728285,0.0002018581,0.0003686251,0.0003471465,0.0001386123,0.0008251592,0.0002123894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003166132,"about_ca_system_score_gemma":0.0003179947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002465368,"about_ca_topic_score_gemma":0.0003337449,"domain_scores_codex":[0.9992294,0.0004915355,0.00006323901,0.00008406966,0.0000733976,0.00005828653],"domain_scores_gemma":[0.9989209,0.0004483603,0.0002277731,0.0001220954,0.00006773981,0.0002130671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6048974,0.0518823,0.03429233,0.001309871,0.00205004,0.001354817,0.0006292118,0.001334144,0.1072329,0.000181394,0.00121394,0.1936216],"study_design_scores_gemma":[0.08767152,0.8203485,0.07854994,0.00007308914,0.0006416843,0.00182919,0.00007153909,0.001534967,0.00754456,0.00007507163,0.001630033,0.00002986303],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979978,0.001450537,0.0001073218,0.00003119498,0.00001156642,0.00009604361,0.00002904884,0.00001529176,0.000261297],"genre_scores_gemma":[0.9992427,0.000270315,0.0001504973,0.00006200841,0.00002454604,0.00006564627,0.00007343406,0.000002227175,0.0001086247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00185838,"threshold_uncertainty_score":0.00982821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152818257891278,"score_gpt":0.2664392740389409,"score_spread":0.2511574482498131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}