{"id":"W3208903573","doi":"10.1111/acel.13497","title":"A trans‐omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases","year":2021,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Phenome; Biology; Mendelian randomization; Genetics; Genome-wide association study; Transcriptome; Gene; Disease; Haptoglobin; Mendelian inheritance; Longevity; Genotype; Computational biology; Bioinformatics; Gene expression; Genome; Single-nucleotide polymorphism; Immunology; Genetic variants; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412394,0.0001077253,0.0002120942,0.00003235543,0.00008136892,0.000008536023,0.00006107099,0.00006496313,0.000005731216],"category_scores_gemma":[0.00004331276,0.0001015731,0.0000615812,0.00005654166,0.00003779509,0.000001870428,0.00003468642,0.00003281815,1.833318e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001914183,"about_ca_system_score_gemma":0.00009849207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001064692,"about_ca_topic_score_gemma":0.0002897056,"domain_scores_codex":[0.9991915,0.0001008186,0.0002123576,0.000280533,0.00003332364,0.0001814278],"domain_scores_gemma":[0.9995838,0.00007521785,0.0001049719,0.0001409325,0.00005444904,0.00004061465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009699874,0.0002702648,0.4578523,0.00005399167,0.0002115011,4.717669e-7,0.0004367181,0.001607427,0.5375826,0.00001426403,0.0001271899,0.001746198],"study_design_scores_gemma":[0.1057347,0.00602242,0.4166436,0.0001414338,0.002607161,0.00003812294,0.01564082,0.02600673,0.3975805,0.001459164,0.02591231,0.002212994],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857656,0.003636804,0.00989386,0.0002057532,0.0001113432,0.0002779807,0.00007490916,0.000005907194,0.00002780607],"genre_scores_gemma":[0.9987162,0.000363052,0.0002566211,0.0001348549,0.00008746258,0.00003453767,0.0003078588,0.00001365749,0.00008577039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1400021,"threshold_uncertainty_score":0.4142033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072474289009829,"score_gpt":0.275999983353293,"score_spread":0.2652752404631947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}