{"id":"W3208903573","doi":"10.1111/acel.13497","title":"A trans‐omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases","year":2021,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Phenome; Biology; Mendelian randomization; Genetics; Genome-wide association study; Transcriptome; Gene; Disease; Haptoglobin; Mendelian inheritance; Longevity; Genotype; Computational biology; Bioinformatics; Gene expression; Genome; Single-nucleotide polymorphism; Immunology; Genetic variants; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003283317,0.0002795268,0.0004304693,0.0007435136,0.0002496397,0.000334423,0.0001940397,0.0002076626,0.001432992],"category_scores_gemma":[0.004176063,0.0001076281,0.0004621075,0.0005725695,0.0003129337,0.00020404,0.0003095728,0.0003097367,0.00007621889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001643468,"about_ca_system_score_gemma":0.000282107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008343263,"about_ca_topic_score_gemma":0.001126489,"domain_scores_codex":[0.9984502,0.0007466297,0.0000842717,0.0005046465,0.0001565754,0.00005779185],"domain_scores_gemma":[0.9974118,0.001112718,0.0006783563,0.0006309263,0.00008176005,0.00008444361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002208204,0.0001104455,0.8128314,0.0001887976,0.002830722,0.001164069,0.0002792985,0.002706608,0.08363315,0.00623615,0.0008437204,0.08696751],"study_design_scores_gemma":[0.00009135661,0.0009666023,0.9625453,0.00003694,0.001338585,0.002952066,0.000156862,0.01097438,0.01000841,0.006066523,0.004825962,0.00003702472],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615183,0.001504123,0.03447229,0.000199658,0.00003521301,0.00003102364,0.001008969,0.000116254,0.001114251],"genre_scores_gemma":[0.9951326,0.0002267371,0.0041118,0.00005033274,0.00001170432,0.00001811984,0.0002165173,0.00001380521,0.0002182449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003283317,"threshold_uncertainty_score":0.01736408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072474289009829,"score_gpt":0.275999983353293,"score_spread":0.2652752404631947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}