{"id":"W3208905095","doi":"10.1111/febs.16250","title":"From structure to molecular condensates: emerging mechanisms for Mediator function","year":2021,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mediator; Enhancer; Coactivator; Chromatin; Promoter; Biology; Transcription (linguistics); Computational biology; RNA polymerase II; Cell biology; Transcription factor; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000744074,0.0007535216,0.001117703,0.001553221,0.0003116223,0.001276134,0.001139304,0.001523146,0.002108577],"category_scores_gemma":[0.0007735146,0.0002650551,0.0003474551,0.001550048,0.001289763,0.002623848,0.001082227,0.002233135,0.001928936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001056529,"about_ca_system_score_gemma":0.0009098996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006002199,"about_ca_topic_score_gemma":0.000729086,"domain_scores_codex":[0.9998331,0.00003223595,0.00002201509,0.00003318762,0.00005649913,0.00002294969],"domain_scores_gemma":[0.9997009,0.0001468038,0.00003040947,0.00001497125,0.00006530556,0.00004167992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000154204,0.00004625913,0.0002528749,0.01715866,0.00008783088,0.0006248724,0.0001681162,0.0006433565,0.007712143,0.04730617,0.04201949,0.8838261],"study_design_scores_gemma":[0.00001604512,0.00006107592,0.0003881108,0.00141825,0.00003906489,0.0009727008,0.00007713509,0.00009978415,0.001072718,0.01040897,0.9854277,0.00001839458],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008216898,0.9985191,0.0001822953,0.0005037629,0.00021613,0.000001376086,0.000007230281,0.000005507647,0.0004823827],"genre_scores_gemma":[0.000809147,0.9980348,0.0001584307,0.00028384,0.0003250644,0.000003721121,0.000013912,0.000001563585,0.0003695728],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002108577,"threshold_uncertainty_score":0.007665634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269555100489819,"score_gpt":0.2868518239077434,"score_spread":0.2741562729028453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}