{"id":"W3208905095","doi":"10.1111/febs.16250","title":"From structure to molecular condensates: emerging mechanisms for Mediator function","year":2021,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mediator; Enhancer; Coactivator; Chromatin; Promoter; Biology; Transcription (linguistics); Computational biology; RNA polymerase II; Cell biology; Transcription factor; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001591191,0.000372235,0.0007670537,0.00008311024,0.0001343002,0.0001441575,0.0003320059,0.0004880709,0.0001209073],"category_scores_gemma":[0.0001014,0.0003316645,0.000602823,0.00008763771,0.00001119203,0.000002443634,0.000142676,0.0003086249,0.000008150038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000062821,"about_ca_system_score_gemma":0.0003900534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002013723,"about_ca_topic_score_gemma":0.000007885251,"domain_scores_codex":[0.9984579,0.00008924929,0.0005129412,0.0004477127,0.0001799614,0.0003121989],"domain_scores_gemma":[0.9988399,0.00001934297,0.000381,0.0003556585,0.0001877526,0.000216411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005729349,0.00006549455,0.000001141374,0.002516081,0.003112252,0.0001092483,0.0001251576,0.0003657907,0.1473142,0.0006862431,0.01598413,0.829663],"study_design_scores_gemma":[0.0002732018,0.0001860166,2.892675e-7,0.001012099,0.0006958124,0.0001824239,0.00008706178,0.00002911217,0.00153488,0.001552911,0.9940274,0.0004188121],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001744162,0.9465432,0.04881809,0.00003636485,0.001800268,0.0003743154,0.0006620435,0.00000627831,0.00001531957],"genre_scores_gemma":[0.0002469233,0.9796252,0.01422568,0.0003063236,0.002250508,0.00004335854,0.00297404,0.0001364718,0.0001914597],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9780433,"threshold_uncertainty_score":0.9999135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269555100489819,"score_gpt":0.2868518239077434,"score_spread":0.2741562729028453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}