{"id":"W3208966130","doi":"10.3390/molecules26216609","title":"Curcumin Acetylsalicylate Extends the Lifespan of Caenorhabditis elegans","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Caenorhabditis elegans; Curcumin; Superoxide dismutase; Reactive oxygen species; Oxidative stress; Paraquat; Catalase; Biology; Gene knockdown; Glutathione; Lipofuscin; Chemistry; Hsp70; Heat shock protein; Biochemistry; Cell biology; Pharmacology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009247685,0.00038147,0.0002372604,0.0002906168,0.0001437066,0.0001121562,0.0001288141,0.0002251573,0.0008460053],"category_scores_gemma":[0.00008242316,0.0001020475,0.0002386047,0.00008492677,0.0001045482,0.000166452,0.0001321953,0.0003313446,0.0001752611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001661406,"about_ca_system_score_gemma":0.0002499958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008863486,"about_ca_topic_score_gemma":0.002020243,"domain_scores_codex":[0.9999468,0.000005649453,0.000008386587,0.00001414295,0.0000141897,0.00001079668],"domain_scores_gemma":[0.9999094,0.00000752087,0.00002567793,0.000007693563,0.00001947964,0.00003033048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009940908,0.00002320019,0.0001087894,0.00006792059,0.00000552716,0.00001751129,0.00000546284,0.00004552499,0.9984607,0.00001522971,0.00003302193,0.001117889],"study_design_scores_gemma":[0.00004649278,0.001709551,0.009156936,0.00002370596,0.00005368384,0.0001147701,0.00002871837,0.0005008339,0.983436,0.00004575491,0.004871737,0.00001173236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927951,0.00376135,0.001278723,0.0001282436,0.00005187776,0.00004259257,0.0006280305,0.0001074943,0.001206726],"genre_scores_gemma":[0.9909801,0.002831369,0.002936385,0.0001069838,0.00001519016,0.00005492192,0.0006573647,0.00002141461,0.00239621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008863486,"threshold_uncertainty_score":0.002830148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007938192936704825,"score_gpt":0.2305209012042126,"score_spread":0.2225827082675077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}