{"id":"W3208966130","doi":"10.3390/molecules26216609","title":"Curcumin Acetylsalicylate Extends the Lifespan of Caenorhabditis elegans","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Caenorhabditis elegans; Curcumin; Superoxide dismutase; Reactive oxygen species; Oxidative stress; Paraquat; Catalase; Biology; Gene knockdown; Glutathione; Lipofuscin; Chemistry; Hsp70; Heat shock protein; Biochemistry; Cell biology; Pharmacology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348975,0.0001705615,0.0001710576,0.00002462687,0.00009925697,0.00003193113,0.0003064553,0.0001275449,0.00005319987],"category_scores_gemma":[0.000104425,0.0001433863,0.0001393401,0.0001152503,0.00016794,0.000002431995,0.0001919423,0.000106558,0.00001416092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006979489,"about_ca_system_score_gemma":0.0001177322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005948532,"about_ca_topic_score_gemma":0.0001231439,"domain_scores_codex":[0.9988713,0.0001109776,0.0002337601,0.0003343688,0.0001802498,0.0002693933],"domain_scores_gemma":[0.999007,0.00001422533,0.00009197409,0.0006591057,0.0001560893,0.00007162119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001097604,0.00006801339,0.001030013,0.0000239051,0.00007871103,0.00001838523,0.0004208784,0.0002791496,0.9918263,0.0005426392,0.00424872,0.00145234],"study_design_scores_gemma":[0.0002683464,0.0001087848,0.004710017,0.00001129807,0.0000435001,0.00005230237,0.00021847,0.00009429597,0.9441906,0.0002848499,0.04982615,0.0001913711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977874,0.003610273,0.01431797,0.001343747,0.0002431613,0.0001090742,0.00005272712,0.00001634763,0.002432689],"genre_scores_gemma":[0.994951,0.0003984451,0.001329425,0.0008243137,0.0002166339,0.00001106422,0.0001043263,0.00003412732,0.002130737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04763566,"threshold_uncertainty_score":0.5847125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007938192936704825,"score_gpt":0.2305209012042126,"score_spread":0.2225827082675077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}