{"id":"W3209015618","doi":"10.2217/fon-2021-1110","title":"The role of Globo H and SSEA-4 in the Development and Progression of Cancer, and their Potential as Therapeutic Targets","year":2021,"lang":"en","type":"review","venue":"Future Oncology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Office of the Chief Medical Examiner","funders":"","keywords":"Glycosylation; Carcinogenesis; Cell biology; Cancer cell; Ceramide; Glycan; Cancer; Embryonic stem cell; Galectin; Cell; Biology; Biochemistry; Glycoprotein; Apoptosis; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004115538,0.0001566501,0.0004334956,0.00003655919,0.0000769388,0.00001476903,0.0001587433,0.0003214116,0.000007516306],"category_scores_gemma":[0.00002491815,0.00007505001,0.00005198595,0.00009425379,0.0001756308,0.000001542525,0.0001804034,0.0001959259,1.748113e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001523518,"about_ca_system_score_gemma":0.0005635352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001701465,"about_ca_topic_score_gemma":0.0003337377,"domain_scores_codex":[0.9988862,0.0003393623,0.0002748215,0.0002352371,0.0001053861,0.000159002],"domain_scores_gemma":[0.9994944,0.00005503446,0.0001742896,0.0001713918,0.00007097092,0.00003389168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003878444,0.00003730736,0.00004594711,0.0005039721,0.00008732774,0.000002757048,0.0002785797,6.775122e-8,0.0008000942,0.0001755653,0.00003529048,0.9979943],"study_design_scores_gemma":[0.0002330068,0.0002324951,0.0001567326,0.0003049035,0.00003166413,0.00005255642,0.0006978437,0.000002138862,0.001360755,0.00005150916,0.9967997,0.00007671321],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005950798,0.9929051,0.000003283919,0.0002498741,0.00007062712,0.0005471705,0.00001158097,0.00000101222,0.0002605184],"genre_scores_gemma":[0.01034466,0.9891314,0.0001037059,0.00003136791,0.0001253986,0.0001329973,0.00006136313,0.0000103144,0.00005882916],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9979176,"threshold_uncertainty_score":0.3060451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578068486255948,"score_gpt":0.3689534633889522,"score_spread":0.3531727785263928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}