{"id":"W3209028141","doi":"10.1016/j.celrep.2021.109950","title":"mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Eye Institute; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institute of Diabetes and Digestive and Kidney Diseases; Boehringer Ingelheim","keywords":"Interneuron; Long-term potentiation; Neuroscience; Schizophrenia (object-oriented programming); Somatostatin; Cognition; Psychology; Biology; Medicine; Internal medicine; Psychiatry; Inhibitory postsynaptic potential","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054082,0.0004477945,0.0003197628,0.000222147,0.0001437234,0.0001843755,0.0002810969,0.00028839,0.002521713],"category_scores_gemma":[0.0001027038,0.0001343071,0.0002493466,0.0001002212,0.0003137705,0.0001778243,0.0001952542,0.0008677618,0.0003920094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280839,"about_ca_system_score_gemma":0.0004065266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001731748,"about_ca_topic_score_gemma":0.00498126,"domain_scores_codex":[0.999933,0.00001030462,0.000004976692,0.000009047206,0.00001096154,0.00003164134],"domain_scores_gemma":[0.99994,0.000005559941,0.00001577317,0.000007496074,0.000005445127,0.00002571786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001316789,0.0002522705,0.0002089077,0.0001093691,0.0000236832,0.000130841,0.00002792091,0.0001826264,0.9900692,0.0004785086,0.0002383527,0.006961493],"study_design_scores_gemma":[0.000305726,0.00492945,0.006986828,0.00002340623,0.00007289027,0.0002431707,0.00008610478,0.001183561,0.9836591,0.0002673067,0.002226345,0.00001600651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99628,0.0004801496,0.0008321773,0.0001856145,0.00003686991,0.00004292435,0.0003802443,0.0001038236,0.001658192],"genre_scores_gemma":[0.9967178,0.0005045099,0.0006499225,0.00004172352,0.000008150919,0.00003476132,0.0002069444,0.00001098878,0.001825164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002521713,"threshold_uncertainty_score":0.008436024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03830471535076553,"score_gpt":0.3222128363112621,"score_spread":0.2839081209604966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}