{"id":"W3209055868","doi":"10.1080/21645515.2021.1976581","title":"Safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, administered concomitantly with influenza vaccine in healthy adults aged ≥50 years: a randomized phase 3 trial (PNEU-FLU)","year":2021,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexus Clinical Research (Canada)","funders":"Merck","keywords":"Tolerability; Immunogenicity; Medicine; Pneumococcal conjugate vaccine; Reactogenicity; Influenza vaccine; Randomized controlled trial; Virology; Live attenuated influenza vaccine; Streptococcus pneumoniae; Vaccination; Immunology; Pediatrics; Adverse effect; Internal medicine; Immune system; Antibiotics; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001516707,0.0005446151,0.0007050944,0.0001391339,0.0001892811,0.0004053575,0.0003402593,0.0008081371,0.001955003],"category_scores_gemma":[0.00132082,0.00030682,0.001129418,0.0001491259,0.0003574983,0.0004731105,0.0002098207,0.001165769,0.0003112962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881429,"about_ca_system_score_gemma":0.00055788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004434054,"about_ca_topic_score_gemma":0.001012954,"domain_scores_codex":[0.9995174,0.0002712017,0.00003358484,0.00005721033,0.00005438677,0.00006623274],"domain_scores_gemma":[0.9994212,0.0001382107,0.0002248637,0.00002882667,0.00005135421,0.0001356357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8856468,0.02193726,0.01322172,0.0007201056,0.001122177,0.00008686409,0.0001407844,0.0005049996,0.01329173,0.00006805224,0.001178534,0.0620809],"study_design_scores_gemma":[0.348915,0.5933937,0.05161288,0.0000751218,0.0007947261,0.0001775264,0.00006836787,0.0007712875,0.002984509,0.0001249057,0.001062829,0.00001901425],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978343,0.001010121,0.00009727079,0.00008058865,0.00003530031,0.0003129655,0.0001994082,0.00001069819,0.0004194447],"genre_scores_gemma":[0.997481,0.0006616774,0.0002586218,0.0001865312,0.00007871076,0.0004957054,0.0003129747,0.000004612572,0.0005201415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001955003,"threshold_uncertainty_score":0.008021235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02941774517563689,"score_gpt":0.338815252832479,"score_spread":0.3093975076568422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}