{"id":"W3209092046","doi":"10.1186/s13072-021-00420-9","title":"The role of MORC3 in silencing transposable elements in mouse embryonic stem cells","year":2021,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; National Institute of General Medical Sciences; National Cancer Institute; University of California, Los Angeles; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; W. M. Keck Foundation; Leids Universitair Medisch Centrum; Howard Hughes Medical Institute","keywords":"Biology; H3K4me3; Epigenetics; Gene silencing; Embryonic stem cell; Genetics; Endogenous retrovirus; Chromatin; Histone; Stem cell; Transposable element; Gene; Cell biology; Gene expression; Mutant; Promoter; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221529,0.0001050258,0.0001610888,0.00001079,0.0001003557,0.00003093994,0.0002177343,0.00006340558,0.0001631071],"category_scores_gemma":[0.00001336993,0.00004648875,0.00005870129,0.0004092051,0.0000298508,0.00002692754,0.00005118249,0.00009194783,0.00001645809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003459666,"about_ca_system_score_gemma":0.00003571066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001863687,"about_ca_topic_score_gemma":0.01056152,"domain_scores_codex":[0.9987914,0.0001189008,0.0004147799,0.000206873,0.0001900447,0.0002779928],"domain_scores_gemma":[0.9995256,0.0001993684,0.00009431643,0.00009337145,0.00004349239,0.00004381969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003472556,0.0001033215,0.02839601,0.000006930527,0.000005522976,0.00000316818,0.0003389504,0.0004067082,0.9591777,0.0001383106,0.0000100247,0.01140983],"study_design_scores_gemma":[0.0002070056,0.00007494062,0.08310825,0.00003733663,0.00000510768,0.000001110368,0.001726794,0.001735762,0.9106053,0.0007213513,0.001659454,0.0001176633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973825,0.001471646,9.885076e-7,0.0002775422,0.00005605389,0.0001665189,0.00004427306,0.000009729881,0.0005907122],"genre_scores_gemma":[0.9985545,0.0003159606,0.0002812836,0.00002299994,0.00003697976,0.00001920015,0.00001489001,0.000001403184,0.0007528295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05471223,"threshold_uncertainty_score":0.5893577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00985709284723491,"score_gpt":0.2001130275605766,"score_spread":0.1902559347133417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}