{"id":"W3209092046","doi":"10.1186/s13072-021-00420-9","title":"The role of MORC3 in silencing transposable elements in mouse embryonic stem cells","year":2021,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; National Institute of General Medical Sciences; National Cancer Institute; University of California, Los Angeles; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; W. M. Keck Foundation; Leids Universitair Medisch Centrum; Howard Hughes Medical Institute","keywords":"Biology; H3K4me3; Epigenetics; Gene silencing; Embryonic stem cell; Genetics; Endogenous retrovirus; Chromatin; Histone; Stem cell; Transposable element; Gene; Cell biology; Gene expression; Mutant; Promoter; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001504177,0.0003122667,0.000170227,0.0004133945,0.0002246988,0.0003235546,0.0003756434,0.0004130201,0.001694644],"category_scores_gemma":[0.0001209669,0.0001383934,0.0003495166,0.0001643357,0.000255059,0.0001271383,0.000333983,0.0004834892,0.0005571239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006376794,"about_ca_system_score_gemma":0.0003372562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092237,"about_ca_topic_score_gemma":0.002513609,"domain_scores_codex":[0.9998212,0.00001263493,0.00001367791,0.00004418847,0.00007481247,0.00003337331],"domain_scores_gemma":[0.9998155,0.0000259597,0.00005402701,0.00002191775,0.00002417279,0.00005848692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005409635,0.00000539372,0.0004966256,0.00002991361,0.000004130939,0.00005311964,0.000007414194,0.00004600999,0.9981901,0.0001127073,0.00004476579,0.0009556116],"study_design_scores_gemma":[0.00001107769,0.00007981223,0.01354879,0.00001248252,0.00002104101,0.0003618855,0.00002536003,0.001525874,0.9803929,0.00007234852,0.00394327,0.00000513077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839883,0.004077915,0.005828876,0.0002277724,0.00005199465,0.00003628226,0.00230841,0.0003141084,0.003166254],"genre_scores_gemma":[0.9905359,0.000702023,0.003330589,0.000129858,0.000007669739,0.00003602296,0.001964219,0.00006852922,0.003225302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001694644,"threshold_uncertainty_score":0.005669177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00985709284723491,"score_gpt":0.2001130275605766,"score_spread":0.1902559347133417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}