{"id":"W3209098923","doi":"10.14309/01.ajg.0000773052.38150.f9","title":"S145 Week 24 Efficacy and Safety Data from PRISM3: A Randomized, Placebo-Controlled Trial Evaluating CP101, an Investigational Orally Administered Microbiome Therapeutic for the Prevention of Recurrent C. difficile Infection","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University Health Network; University of Toronto; St Joseph's Health Care; Western University; University of Calgary","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Randomized controlled trial; Clinical trial; Dosing; Adverse effect; Clostridium difficile; Antibiotics; Guideline; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003458107,0.00161802,0.003173226,0.0004782288,0.0005042004,0.001395018,0.0009760197,0.00270704,0.01491414],"category_scores_gemma":[0.005032027,0.0005849004,0.003653292,0.0005628032,0.001200227,0.001205118,0.0004580419,0.003293128,0.001545817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005377403,"about_ca_system_score_gemma":0.002034131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004281268,"about_ca_topic_score_gemma":0.0008126569,"domain_scores_codex":[0.9975198,0.001487224,0.0002417454,0.0003163989,0.0002430237,0.0001917547],"domain_scores_gemma":[0.9968149,0.00112655,0.0008890047,0.0002798779,0.0003912514,0.0004984136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9659529,0.004649334,0.0006980901,0.003493724,0.002466586,0.000059951,0.00004181588,0.0003656344,0.002921145,0.0001932947,0.002196683,0.01696087],"study_design_scores_gemma":[0.8996211,0.09093709,0.003176413,0.0002537119,0.001721004,0.00008279789,0.00002436585,0.0005017558,0.001039807,0.0002428101,0.002370154,0.00002892609],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9258032,0.02374659,0.003563429,0.002220108,0.001387756,0.01913804,0.01214894,0.0005178433,0.01147424],"genre_scores_gemma":[0.9642735,0.005029516,0.003857842,0.002293549,0.0006943056,0.01447623,0.004788754,0.0000552152,0.004531074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01491414,"threshold_uncertainty_score":0.04989272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1009273782469944,"score_gpt":0.3842550973453944,"score_spread":0.2833277190984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}