{"id":"W3209164296","doi":"10.1017/s0033291721001070","title":"Global cognitive dysfunction and <i>β</i>-amyloid neuropathology in late-life and treatment-resistant major depression","year":2021,"lang":"en","type":"article","venue":"Psychological Medicine","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Taipei Veterans General Hospital","keywords":"Neuropathology; Late life depression; Major depressive disorder; Depression (economics); Neurocognitive; Montreal Cognitive Assessment; Cognition; Psychology; Internal medicine; Dementia; Cognitive decline; Psychiatry; Effects of sleep deprivation on cognitive performance; Medicine; Clinical psychology; Disease; Cognitive impairment","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002538353,0.0002809295,0.0002586335,0.0003966238,0.0002145581,0.0003382765,0.0001334993,0.0002734522,0.0009375379],"category_scores_gemma":[0.0007583383,0.0001453393,0.000202026,0.0002022461,0.0001715596,0.0001295635,0.000157574,0.0002342627,0.000119882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001899842,"about_ca_system_score_gemma":0.00007364779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496402,"about_ca_topic_score_gemma":0.002328271,"domain_scores_codex":[0.9999076,0.00002985415,0.00001489428,0.00002214389,0.00001273729,0.00001272814],"domain_scores_gemma":[0.9996341,0.00004950662,0.0001867286,0.00001658416,0.00003175317,0.00008134558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007776784,0.0001193769,0.9947509,0.00001791418,0.00007844078,0.0003604458,0.000073893,0.0000311337,0.001765983,0.00001293179,0.0000715377,0.001939811],"study_design_scores_gemma":[0.00001679447,0.0001834298,0.9990355,0.000002462263,0.00001441666,0.0005688416,0.00003726719,0.00005718858,0.00004993435,0.000008226618,0.00002491106,0.000001081153],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996737,0.0001135801,0.00002203399,0.00001005885,0.000002186565,0.000004887915,0.00004477802,0.000001278288,0.0001274938],"genre_scores_gemma":[0.9998322,0.00003393841,0.00002344538,0.00001250742,0.000003562969,0.000002081427,0.0000540644,3.064226e-7,0.0000378745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496402,"threshold_uncertainty_score":0.003136396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03403522807157672,"score_gpt":0.3611836818668638,"score_spread":0.3271484537952871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}