{"id":"W3209164903","doi":"10.1093/ajcp/aqab191.053","title":"HER2 testing in metastatic breast cancer – is reflex in situ hybridization necessary in cases that are equivocal by immunohistochemistry?","year":2021,"lang":"en","type":"article","venue":"American Journal of Clinical Pathology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Immunohistochemistry; Pathology; Metastatic breast cancer; Metastasis; In situ hybridization; Breast cancer; Incidence (geometry); Cancer; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00324101,0.0002845142,0.0004393847,0.001490736,0.0004153092,0.0009019137,0.0007672588,0.0008036371,0.001795771],"category_scores_gemma":[0.01067077,0.0002722699,0.0002857282,0.001042237,0.001140559,0.0009646947,0.0003527085,0.0004525591,0.0009032746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003752125,"about_ca_system_score_gemma":0.0004954484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001335989,"about_ca_topic_score_gemma":0.002242613,"domain_scores_codex":[0.9983934,0.0005379478,0.0003163795,0.0001651746,0.000414371,0.0001727858],"domain_scores_gemma":[0.9950715,0.001700989,0.001620154,0.0002607009,0.000977453,0.0003692505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002272759,0.00003788022,0.9284812,0.0002243972,0.00003662021,0.02731889,0.0002000533,0.0001193091,0.003686476,0.0001539884,0.002009778,0.03750411],"study_design_scores_gemma":[0.00003072669,0.0005274211,0.6841633,0.0009022987,0.0001428197,0.2877443,0.00337849,0.001696675,0.009635889,0.0008885683,0.01084363,0.00004574876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717512,0.01445173,0.00237378,0.002539169,0.000222167,0.00004262767,0.0001977251,0.00008025386,0.008341422],"genre_scores_gemma":[0.9954151,0.002417938,0.001353097,0.0003209383,0.0001675263,0.000006336067,0.00009205486,0.00001583285,0.0002111407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00324101,"threshold_uncertainty_score":0.01714033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.155043225926168,"score_gpt":0.5059862879618359,"score_spread":0.3509430620356678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}