{"id":"W3209179037","doi":"10.1161/hypertensionaha.121.17977","title":"Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time","year":2021,"lang":"en","type":"article","venue":"Hypertension","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Tachyphylaxis; Agonist; Receptor; G protein-coupled receptor; Internalization; Angiotensin II; Signal transduction; Endogenous agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163947,0.000174394,0.0001986477,0.00002236546,0.0002352608,0.0000359994,0.0001156217,0.0002214897,0.0007458537],"category_scores_gemma":[0.0001474444,0.0001639843,0.0001097488,0.0001617675,0.00003581997,0.000005078607,0.000168968,0.00009167052,0.0002412755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001264253,"about_ca_system_score_gemma":0.00008764175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003113809,"about_ca_topic_score_gemma":0.000003425859,"domain_scores_codex":[0.9988121,0.00006021375,0.0001877505,0.0004995084,0.0001795457,0.0002609009],"domain_scores_gemma":[0.9990709,0.00001307257,0.00005835882,0.0004202158,0.0003335015,0.000103967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000323417,0.00003944774,0.00001726276,0.000002689423,0.00001493584,0.000009098992,0.0000143651,0.000001318459,0.6621907,0.000009063285,0.3367583,0.0009104268],"study_design_scores_gemma":[0.0001991264,0.0002447793,0.00002689055,0.00002272187,0.00001297551,0.00005030671,0.00002238671,0.0001008492,0.7458676,0.00003034499,0.2532451,0.0001768655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911337,0.005696627,0.0003199492,0.001452451,0.0005206217,0.0000998067,0.00004026041,0.00003530587,0.0007013161],"genre_scores_gemma":[0.9565997,0.001106791,0.01004165,0.005064679,0.0004314529,0.000005443761,0.001098962,0.00007380436,0.02557749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08367692,"threshold_uncertainty_score":0.8166575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226857218438612,"score_gpt":0.2162154844645275,"score_spread":0.2039469122801414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}