{"id":"W3209179037","doi":"10.1161/hypertensionaha.121.17977","title":"Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time","year":2021,"lang":"en","type":"article","venue":"Hypertension","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Tachyphylaxis; Agonist; Receptor; G protein-coupled receptor; Internalization; Angiotensin II; Signal transduction; Endogenous agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001890124,0.0003031361,0.0002746751,0.0001176052,0.0001055123,0.0002729693,0.0001872349,0.0002857821,0.0007021871],"category_scores_gemma":[0.0002276293,0.0001161455,0.0001821812,0.0001500889,0.0002139459,0.000250318,0.0001264823,0.0005587864,0.0002243321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003225641,"about_ca_system_score_gemma":0.0001479889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003738297,"about_ca_topic_score_gemma":0.0003188721,"domain_scores_codex":[0.9997668,0.00004602192,0.00001501872,0.00006066482,0.000072093,0.0000394293],"domain_scores_gemma":[0.9998387,0.00004673919,0.00007122535,0.00001186728,0.00001563624,0.00001580159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009937046,0.00001618496,0.0002863072,0.00003608676,0.000006007489,0.00003392178,0.00001282058,0.0001124625,0.9979033,0.000158299,0.00002780045,0.001307375],"study_design_scores_gemma":[0.000006872589,0.0003888896,0.008610032,0.00000545373,0.00001916888,0.0002768833,0.0000229588,0.003044526,0.9861713,0.0001062523,0.001335587,0.00001208206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678536,0.006160247,0.0226993,0.0001581522,0.00004112773,0.00004560798,0.0005340254,0.0001333791,0.002374606],"genre_scores_gemma":[0.9922242,0.002278882,0.004085614,0.00007020157,0.00001420717,0.00005731554,0.0002703412,0.00001926944,0.0009800192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007021871,"threshold_uncertainty_score":0.002349019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226857218438612,"score_gpt":0.2162154844645275,"score_spread":0.2039469122801414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}