{"id":"W3209200305","doi":"10.3390/pharmaceutics13111855","title":"Targeting of Inhaled Therapeutics to the Small Airways: Nanoleucine Carrier Formulations","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Exhalation; Particle size; Inhalation; Aerosol; Dry-powder inhaler; Small airways; Drug delivery; Suspension (topology); Particle (ecology); Nanoparticle; Respiratory tract; Deposition (geology); Materials science; Chemistry; Chemical engineering; Nanotechnology; Chromatography; Lung; Medicine; Respiratory system; Anesthesia; Organic chemistry; Inhaler","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002400627,0.0001153762,0.0001865587,0.00006724421,0.0001349004,0.00001173366,0.00008344822,0.00006048492,0.0002434377],"category_scores_gemma":[0.000092741,0.00008127706,0.0000956385,0.0003948674,0.00004421455,0.00003163578,0.00006432628,0.0002127285,0.00003759855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003962606,"about_ca_system_score_gemma":0.000193942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002428522,"about_ca_topic_score_gemma":0.000004700456,"domain_scores_codex":[0.9990207,0.00007040513,0.000332919,0.0001505863,0.0002264145,0.0001989738],"domain_scores_gemma":[0.9989647,0.00008757126,0.00008095259,0.0002668034,0.0004868539,0.0001131138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003043926,0.0006087381,0.0112442,0.0004015587,0.0006559823,0.0002479863,0.008854282,0.01046072,0.9068325,0.001531616,0.004921701,0.05393637],"study_design_scores_gemma":[0.00146542,0.00005704715,0.00061376,0.00006681459,0.000352376,0.00007338572,0.0007258762,0.01687189,0.4720725,0.00001965181,0.5075266,0.0001546725],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750624,0.003219104,0.005316818,0.009451095,0.0006943052,0.0006561825,0.00004931225,0.00008115968,0.00546963],"genre_scores_gemma":[0.9862059,0.0002056143,0.001469902,0.01003083,0.0002712545,0.00001044298,0.0000292751,0.00002455785,0.001752159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5026049,"threshold_uncertainty_score":0.3314382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08093616182052661,"score_gpt":0.3490155643637853,"score_spread":0.2680794025432587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}