{"id":"W3209237487","doi":"10.14309/01.ajg.0000778692.42211.5f","title":"S1290 Efficacy, Safety, and Pharmacokinetics of Infliximab Dose Escalation in Pediatric Patients With Crohn’s Disease or Ulcerative Colitis: An Analysis of the DEVELOP Registry","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Infliximab; Ulcerative colitis; Internal medicine; Adverse effect; Inflammatory bowel disease; Gastroenterology; Pharmacokinetics; Faecal calprotectin; Disease; Calprotectin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003107571,0.000284019,0.0005476056,0.001272382,0.0002174534,0.0006576925,0.0003264115,0.0002552117,0.001005713],"category_scores_gemma":[0.006458167,0.0002253156,0.0005761698,0.002620161,0.0003194636,0.0005309519,0.0005775597,0.0003993098,0.000253626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005255295,"about_ca_system_score_gemma":0.0007750279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001187662,"about_ca_topic_score_gemma":0.001721053,"domain_scores_codex":[0.9975014,0.0009218136,0.0003889553,0.0003678907,0.0007033229,0.0001165637],"domain_scores_gemma":[0.9886715,0.002827568,0.006282041,0.0009989513,0.0008285231,0.000391427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001161377,0.00006868257,0.9911197,0.00005121911,0.0001701584,0.00005401404,0.00004839562,0.0002480857,0.0003637184,0.00004151262,0.0005639686,0.006109198],"study_design_scores_gemma":[0.0002156345,0.001083087,0.9951169,0.00001963347,0.0001669365,0.0004238523,0.00005708614,0.000436477,0.0004836736,0.00002304176,0.001966272,0.000007390084],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916773,0.0004166258,0.0002850964,0.00005371157,0.000003600716,0.00007350034,0.006650647,0.00001455249,0.0008250247],"genre_scores_gemma":[0.9816558,0.000621931,0.000757994,0.00008814773,0.00003186003,0.000158461,0.01642773,0.00001197224,0.0002461716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003107571,"threshold_uncertainty_score":0.01643461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004830159441190956,"score_gpt":0.2405387071891161,"score_spread":0.2357085477479251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}