{"id":"W3209273891","doi":"10.1111/liv.15090","title":"Efficacy and safety of givosiran for acute hepatic porphyria: 24‐month interim analysis of the randomized phase 3 ENVISION study","year":2021,"lang":"en","type":"article","venue":"Liver International","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton","funders":"Alnylam Pharmaceuticals","keywords":"Porphobilinogen; Medicine; Crossover study; Placebo; Porphyria; Gastroenterology; Interim analysis; Internal medicine; Adverse effect; Randomized controlled trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005795565,0.001412231,0.002802287,0.0003987377,0.0004559355,0.001154696,0.0008033874,0.001308458,0.004761898],"category_scores_gemma":[0.002833025,0.0005335499,0.002156666,0.0003092864,0.00106643,0.0009838229,0.0004703332,0.002526187,0.0009537284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006267276,"about_ca_system_score_gemma":0.00127094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003069613,"about_ca_topic_score_gemma":0.0005240361,"domain_scores_codex":[0.9984641,0.0009497939,0.00006766842,0.0001433757,0.0001216731,0.000253358],"domain_scores_gemma":[0.9976828,0.0006035716,0.0007275472,0.0003276927,0.0001739722,0.0004844282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9680581,0.006384188,0.002254134,0.0001510726,0.0007415785,0.00007245041,0.00006219427,0.000661729,0.004575099,0.0001094404,0.001262871,0.01566719],"study_design_scores_gemma":[0.7610514,0.2227069,0.0105353,0.00003610657,0.0006770508,0.000135055,0.00004367824,0.001159768,0.001825477,0.0003185016,0.001475286,0.00003548409],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891819,0.001811749,0.001538502,0.0004800393,0.0002037327,0.00326607,0.001759622,0.0002348938,0.001523445],"genre_scores_gemma":[0.9884836,0.0006687351,0.002324463,0.0005521073,0.0002200926,0.004171889,0.001936109,0.00004897671,0.001593976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005795565,"threshold_uncertainty_score":0.03065026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038324100599043,"score_gpt":0.3041354390305853,"score_spread":0.2937521980245948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}