{"id":"W3209362577","doi":"10.1016/j.pan.2021.10.007","title":"The unfolded protein response: An emerging therapeutic target for pancreatitis and pancreatic ductal adenocarcinoma","year":2021,"lang":"en","type":"review","venue":"Pancreatology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute","funders":"","keywords":"Unfolded protein response; Pancreatitis; Medicine; Pancreatic cancer; Context (archaeology); Pancreas; Disease; Acinar cell; Cancer research; Acute pancreatitis; Cancer; Internal medicine; Endoplasmic reticulum; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000454598,0.0006255647,0.001496882,0.00007796394,0.0004514368,0.0001161144,0.0004140866,0.0005384706,0.00002299869],"category_scores_gemma":[0.0005701153,0.0004474881,0.0004721323,0.0001395505,0.0003294655,0.00000705706,0.0001915674,0.0002267191,0.000004693807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003029356,"about_ca_system_score_gemma":0.0005817726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002671945,"about_ca_topic_score_gemma":0.00001981897,"domain_scores_codex":[0.9963196,0.001195779,0.0006307844,0.00101552,0.0001466344,0.0006916908],"domain_scores_gemma":[0.9978953,0.0004003873,0.0003422301,0.0009825978,0.0001287876,0.0002506683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002867341,0.0004000714,0.003060123,0.01483884,0.005465982,0.001142342,0.0001637866,0.000002587617,0.003116291,0.008944394,0.001913408,0.9580848],"study_design_scores_gemma":[0.0007889044,0.0007400668,0.0001183889,0.001070169,0.001761993,0.00169004,0.0001413604,0.00002045889,0.0003460044,0.0003822261,0.9922429,0.0006974678],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03758256,0.9599931,0.000206816,0.00009935878,0.0001747438,0.001586923,0.0002448066,0.00002736593,0.00008432082],"genre_scores_gemma":[0.008731049,0.9860106,0.0006933568,0.00006143017,0.0003231301,0.002061208,0.001116098,0.0001243632,0.0008787568],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9903295,"threshold_uncertainty_score":0.9997977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02619617912222705,"score_gpt":0.3270075886454621,"score_spread":0.3008114095232351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}