{"id":"W3209378758","doi":"10.1002/pds.5379","title":"Do contemporary antiretrovirals increase the risk of end‐stage liver disease? Signals from patients starting therapy in the North American AIDS Cohort Collaboration on Research and Design","year":2021,"lang":"en","type":"article","venue":"Pharmacoepidemiology and Drug Safety","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"HIV Legal Network; McGill University; University of Calgary; McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute on Aging; National Eye Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of General Medical Sciences; National Institute on Alcohol Abuse and Alcoholism; National Cancer Institute; National Institutes of Health","keywords":"Atazanavir; Medicine; Darunavir; Efavirenz; Emtricitabine; Coinfection; Hazard ratio; Lamivudine; Internal medicine; Hepatitis C; Liver disease; Cohort; Abacavir; Hepatitis B; Raltegravir; Antiretroviral therapy; Virology; Viral load; Human immunodeficiency virus (HIV); Confidence interval; Chronic hepatitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05962625,0.0005776316,0.0008328275,0.0009999869,0.0006955386,0.001757964,0.001092205,0.001337867,0.001572187],"category_scores_gemma":[0.1204357,0.0004738938,0.001568677,0.001583613,0.000591758,0.0006896628,0.001386684,0.001214135,0.0001520035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005991037,"about_ca_system_score_gemma":0.001577707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0122532,"about_ca_topic_score_gemma":0.01215969,"domain_scores_codex":[0.9586872,0.03447147,0.001443582,0.002379672,0.002131589,0.0008864381],"domain_scores_gemma":[0.8372446,0.1066194,0.03483767,0.01356217,0.004892922,0.002843265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001343313,0.00003202754,0.9857598,0.00007179163,0.001222624,0.0000740899,0.0002133373,0.001131707,0.0001047618,0.0006079846,0.0008343473,0.008604232],"study_design_scores_gemma":[0.0003923671,0.0004950665,0.9724512,0.0002668787,0.001886072,0.0003079616,0.0002757913,0.01663753,0.000351389,0.003178833,0.003682141,0.00007474879],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640872,0.0071154,0.01770972,0.00364638,0.0001354332,0.0002046207,0.003943264,0.0000781962,0.0030798],"genre_scores_gemma":[0.9945229,0.0005238455,0.00260083,0.0005826412,0.00007270451,0.00009186575,0.001394147,0.00001101172,0.0001999659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05962625,"threshold_uncertainty_score":0.3153375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07004946016774118,"score_gpt":0.3664767678041334,"score_spread":0.2964273076363922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}