{"id":"W3209413066","doi":"10.1002/elsc.202100045","title":"Design of a synthesis‐friendly hypoxia‐responsive promoter for cell‐based therapeutics","year":2021,"lang":"en","type":"article","venue":"Engineering in Life Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Promoter; Cell biology; HEK 293 cells; Reporter gene; Cell; Computational biology; RHOA; Cell culture; Gene; Genetics; Signal transduction; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003612655,0.00009881306,0.0001390484,0.00006564616,0.00003294603,0.00001338625,0.000162762,0.00006605691,0.000006009446],"category_scores_gemma":[0.000358673,0.00009178787,0.00005714794,0.0002054933,0.00007348894,0.000005166349,0.00002652659,0.00003996051,5.19055e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006012137,"about_ca_system_score_gemma":0.0003396184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002646915,"about_ca_topic_score_gemma":0.000001840041,"domain_scores_codex":[0.999237,0.00003733503,0.0001558542,0.0002454013,0.0001174676,0.0002069615],"domain_scores_gemma":[0.999574,0.0001195273,0.00004320785,0.0001499119,0.000069562,0.00004375561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004636775,0.00004787646,0.00005652944,0.0000410585,0.00001086598,5.161604e-7,0.00006468371,0.05864904,0.9401801,0.00004170564,0.0001469954,0.0007142531],"study_design_scores_gemma":[0.0003726339,0.0002179014,0.0004457263,0.00002615733,0.00001470912,0.0000019586,0.000068393,0.01572086,0.9657497,0.00001638936,0.01722036,0.0001452117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6820222,0.009076128,0.3068184,0.0002787056,0.001151734,0.0004548329,0.00002567313,0.00001989306,0.0001524735],"genre_scores_gemma":[0.9608849,0.0001759252,0.03836984,0.0001387639,0.0002630021,0.00007205857,0.000003279876,0.0000133885,0.00007884607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2788628,"threshold_uncertainty_score":0.3743001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02177553346375711,"score_gpt":0.25425000403111,"score_spread":0.2324744705673529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}