{"id":"W3209413066","doi":"10.1002/elsc.202100045","title":"Design of a synthesis‐friendly hypoxia‐responsive promoter for cell‐based therapeutics","year":2021,"lang":"en","type":"article","venue":"Engineering in Life Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Promoter; Cell biology; HEK 293 cells; Reporter gene; Cell; Computational biology; RHOA; Cell culture; Gene; Genetics; Signal transduction; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002753631,0.0002901614,0.0003436702,0.0001555151,0.0001601368,0.0002602098,0.0002867614,0.0003420261,0.0006011628],"category_scores_gemma":[0.0002047168,0.0001716791,0.0002934375,0.0001791554,0.0002179906,0.0002179584,0.0002194634,0.0004748203,0.0004020419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003317556,"about_ca_system_score_gemma":0.0005232158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002982043,"about_ca_topic_score_gemma":0.0004122065,"domain_scores_codex":[0.999832,0.00002627932,0.00001707412,0.00003663179,0.0000550975,0.00003294832],"domain_scores_gemma":[0.999884,0.000022169,0.0000369201,0.000007312059,0.00002423229,0.00002533349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004027561,0.00001989863,0.00007261055,0.00006628823,0.000002539646,0.00003633016,0.00001927531,0.0006867925,0.9964491,0.0003789052,0.00003314448,0.002194767],"study_design_scores_gemma":[0.00002213841,0.0001523002,0.0002287036,0.000007668128,0.000008854119,0.00008817545,0.00001450418,0.003400955,0.9907227,0.00009528449,0.005251306,0.000007350277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6579143,0.002170337,0.3337347,0.000437585,0.0001282366,0.0006798471,0.0005429516,0.0004722552,0.003919908],"genre_scores_gemma":[0.7650401,0.002248674,0.2264976,0.0001480679,0.00004359004,0.0006902151,0.0007043696,0.000141535,0.00448586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006011628,"threshold_uncertainty_score":0.002407074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02177553346375711,"score_gpt":0.25425000403111,"score_spread":0.2324744705673529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}