{"id":"W3209426648","doi":"10.3390/cancers13215543","title":"Statins Enhance the Molecular Response in Chronic Myeloid Leukemia when Combined with Tyrosine Kinase Inhibitors","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Samsung; Ministry of Science and ICT, South Korea; National Research Foundation of Korea; National Research Foundation","keywords":"Imatinib; Statin; Medicine; Myeloid leukemia; Rosuvastatin; Nilotinib; Pharmacology; Tyrosine-kinase inhibitor; Combination therapy; Cancer research; Tyrosine kinase; Immunology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002488086,0.0002784306,0.0003801206,0.00008699879,0.00008412021,0.00002775568,0.0001406037,0.00009423459,0.0002973185],"category_scores_gemma":[0.0001936603,0.0002003839,0.00007915793,0.0005637059,0.0002172059,0.00008009034,0.00006603725,0.0004027357,0.00003839521],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03452907,"about_ca_system_score_gemma":0.01828266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001033183,"about_ca_topic_score_gemma":0.001498435,"domain_scores_codex":[0.9980826,0.0001902898,0.0003146614,0.0005077681,0.000412983,0.0004916397],"domain_scores_gemma":[0.9986458,0.0001709583,0.0001146157,0.0007739089,0.0001260193,0.0001686439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03042629,0.0002018107,0.005650961,0.0006210032,0.0008481821,0.01473401,0.006915211,0.02178599,0.8862009,0.0006519476,0.01342511,0.01853857],"study_design_scores_gemma":[0.02201022,0.003228245,0.01678854,0.001462126,0.0002848758,0.0002027967,0.001236637,0.002337301,0.9213864,0.0001113346,0.03033681,0.000614712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903691,0.005230876,0.00009560178,0.0026072,0.0001564011,0.0006357263,0.000020168,0.00005996236,0.0008249704],"genre_scores_gemma":[0.9948725,0.0002899995,0.0005654581,0.001175958,0.0001009461,0.0001903524,0.00006462967,0.00006094162,0.002679194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03518549,"threshold_uncertainty_score":0.9872828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009205311423751533,"score_gpt":0.2608467679117187,"score_spread":0.2516414564879672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}