{"id":"W3209426648","doi":"10.3390/cancers13215543","title":"Statins Enhance the Molecular Response in Chronic Myeloid Leukemia when Combined with Tyrosine Kinase Inhibitors","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Samsung; Ministry of Science and ICT, South Korea; National Research Foundation of Korea; National Research Foundation","keywords":"Imatinib; Statin; Medicine; Myeloid leukemia; Rosuvastatin; Nilotinib; Pharmacology; Tyrosine-kinase inhibitor; Combination therapy; Cancer research; Tyrosine kinase; Immunology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003601295,0.0002003383,0.0004767228,0.0002656076,0.0001406859,0.0002535542,0.00008179646,0.0001774008,0.000622985],"category_scores_gemma":[0.0006182955,0.00008966617,0.0002972885,0.0002374821,0.0001173592,0.0001391363,0.0002435127,0.0002557125,0.0001326699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001695952,"about_ca_system_score_gemma":0.000175375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002989068,"about_ca_topic_score_gemma":0.0007320003,"domain_scores_codex":[0.999706,0.0001017347,0.00003783113,0.00002489001,0.00006119476,0.0000685226],"domain_scores_gemma":[0.9997888,0.0000457036,0.00008288492,0.00001228969,0.00002052579,0.00004984897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01410132,0.0009572277,0.2041357,0.0005226844,0.0004635282,0.001238575,0.0001974481,0.0007929796,0.6614018,0.0002500869,0.0006531549,0.1152855],"study_design_scores_gemma":[0.0006577275,0.0163523,0.792716,0.00007033812,0.0009767702,0.002842021,0.0001944993,0.00217326,0.1731431,0.0002851749,0.01056037,0.00002854041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941196,0.004667296,0.0002639109,0.000106268,0.00001768265,0.00002800534,0.00005969739,0.00001359301,0.000723927],"genre_scores_gemma":[0.9983889,0.0009346501,0.0002401363,0.00005633193,0.00002525731,0.00001612383,0.0000806899,0.000002295594,0.000255624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000622985,"threshold_uncertainty_score":0.002084076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009205311423751533,"score_gpt":0.2608467679117187,"score_spread":0.2516414564879672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}