{"id":"W3209437137","doi":"10.3389/fcell.2021.727836","title":"Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Topoisomerase; Biology; DNA damage; DNA; Genome instability; DNA repair; Gene knockdown; Cell biology; Molecular biology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174746,0.0004869857,0.00032895,0.0002939238,0.0002975554,0.0005177502,0.0001867569,0.0005053267,0.002036939],"category_scores_gemma":[0.0001688312,0.0001793073,0.0003695359,0.000134386,0.0002932014,0.0002896053,0.0002244014,0.0006259826,0.0008507566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004750071,"about_ca_system_score_gemma":0.000231322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006577047,"about_ca_topic_score_gemma":0.00046709,"domain_scores_codex":[0.9997821,0.0000375523,0.00001128779,0.00006608609,0.00005727735,0.00004558455],"domain_scores_gemma":[0.9998232,0.00002160298,0.00004076189,0.00001380459,0.00003107265,0.00006956126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009697147,0.00001614335,0.0001680702,0.00006424288,0.000006156436,0.00006633363,0.00001049807,0.00003380229,0.9986219,0.0001222745,0.00006001152,0.0007334483],"study_design_scores_gemma":[0.00001448,0.0001886278,0.01171925,0.00001710293,0.00001421968,0.0005418952,0.00005102963,0.00086108,0.981995,0.00009689108,0.004491002,0.00000940006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647223,0.0196883,0.008508827,0.0006606976,0.0001423821,0.00005030754,0.001072965,0.000355368,0.004798932],"genre_scores_gemma":[0.9916174,0.0022867,0.00184342,0.00009262627,0.00001996065,0.00002888364,0.0005740734,0.00002962217,0.00350726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036939,"threshold_uncertainty_score":0.006814182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009609082583637144,"score_gpt":0.2116057041945923,"score_spread":0.2019966216109552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}