{"id":"W3209437137","doi":"10.3389/fcell.2021.727836","title":"Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Topoisomerase; Biology; DNA damage; DNA; Genome instability; DNA repair; Gene knockdown; Cell biology; Molecular biology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006036292,0.00009905585,0.0001218104,0.00002870196,0.00009376148,0.00000404782,0.00007459395,0.0001308946,0.00002628163],"category_scores_gemma":[0.00001156388,0.00007542408,0.00004813338,0.00009917138,0.00007179331,0.000001650729,0.000217447,0.00006426771,0.000001775687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003646498,"about_ca_system_score_gemma":0.0001446634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001652185,"about_ca_topic_score_gemma":0.0001253339,"domain_scores_codex":[0.999359,0.00004965124,0.0001633393,0.0002370042,0.00003974904,0.0001512937],"domain_scores_gemma":[0.9997596,0.000004125086,0.00004782057,0.0001248165,0.00002590836,0.00003779397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003701172,0.00004471597,0.006091398,0.000009431764,0.00001962964,0.000001260515,0.00005805782,5.035611e-7,0.9881126,0.00004153503,0.001478115,0.004105714],"study_design_scores_gemma":[0.000456717,0.00006830901,0.0009801214,0.000009964289,0.000005703509,0.00001003183,0.0004428473,0.000002712737,0.9434457,0.0002194402,0.0542578,0.0001006588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960043,0.0012597,0.0003303798,0.0001654377,0.0007037914,0.0001479213,0.00002497555,0.000002783584,0.001360714],"genre_scores_gemma":[0.9934864,0.0002013139,0.001960723,0.0002159664,0.00003874962,0.00002946593,0.00007171075,0.000008093755,0.003987579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05277969,"threshold_uncertainty_score":0.3075705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009609082583637144,"score_gpt":0.2116057041945923,"score_spread":0.2019966216109552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}