{"id":"W3209439552","doi":"10.1101/2021.10.13.21262206","title":"Salicylic acid and risk of colorectal cancer: a two sample Mendelian randomization study","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Memorial University of Newfoundland","funders":"Medicinska fakulteten, Umeå Universitet; Health and Social Care Research and Development Division; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Economic and Social Research Council; Medical Research Council; Canadian Institutes of Health Research; NIHR Cambridge Biomedical Research Centre; NIHR BioResource; Chonnam National University Hwasun Hospital; Hellenic Health Foundation; Wereld Kanker Onderzoek Fonds; Xunta de Galicia; Innovative Medicines Initiative; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; KWF Kankerbestrijding; Vetenskapsrådet; Cambridge University Hospitals; Stockholms Läns Landsting; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Bundesministerium für Bildung und Forschung; British Heart Foundation; Ministerio de Economía y Competitividad; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Cancer Research Foundation in Northern Sweden; Karolinska Institutet; University of Cambridge; ZonMw; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; McGill University; Public Health Agency; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Ministerstvo Zdravotnictví Ceské Republiky; Engineering and Physical Sciences Research Council; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; European Commission; Generalitat de Catalunya; Food Standards Agency; Department of Health and Social Care; Cancer Research UK; Umeå Universitet; Chonnam National University; Centres de Recerca de Catalunya; Conseil Régional des Pays de la Loire; Génome Québec; NHS Blood and Transplant; University of South Florida; Swedish Cancer Foundation; Moffitt Cancer Center; Pelotonia; Division of Cancer Prevention, National Cancer Institute; Scottish Government; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Institut Gustave-Roussy; Grantová Agentura České Republiky; Johns Hopkins University; Centre International de Recherche sur le Cancer; World Cancer Research Fund International; Memorial Sloan-Kettering Cancer Center; Association Anne de Bretagne Genetique; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Fred Hutchinson Cancer Research Center; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; U.S. Department of Health and Human Services; Office of Research Infrastructure Programs, National Institutes of Health; American Institute for Cancer Research","keywords":"Aspirin; Mendelian randomization; Colorectal cancer; Single-nucleotide polymorphism; Medicine; Internal medicine; Oncology; Bioinformatics; Cancer; Biology; Genetics; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01181066,0.001016454,0.001363888,0.0009723091,0.0005778116,0.0006747825,0.001196101,0.00117608,0.003885027],"category_scores_gemma":[0.01916254,0.0006204223,0.001824444,0.001110648,0.0008785127,0.000452079,0.0005642196,0.0006847435,0.0003407347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003490951,"about_ca_system_score_gemma":0.0006408292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002058126,"about_ca_topic_score_gemma":0.001156976,"domain_scores_codex":[0.98291,0.01267468,0.0006494552,0.002401032,0.0009323018,0.0004324777],"domain_scores_gemma":[0.9918498,0.004221201,0.001392687,0.00187448,0.0003515339,0.0003103176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.09586687,0.002863149,0.8309034,0.0007942781,0.01370707,0.003432127,0.001314152,0.003982163,0.01249244,0.00651816,0.003065662,0.02506062],"study_design_scores_gemma":[0.03377067,0.03705966,0.7909092,0.0001946864,0.01725241,0.007784838,0.000746132,0.08891835,0.005236592,0.009199536,0.008590593,0.0003372449],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814506,0.0004919406,0.01560062,0.0001667169,0.00006644169,0.000775431,0.0006847375,0.00008990213,0.0006736201],"genre_scores_gemma":[0.990426,0.00006063088,0.007745352,0.0001016699,0.0000253099,0.0007367724,0.0003507545,0.00001968892,0.0005337897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01181066,"threshold_uncertainty_score":0.0624615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949960991538241,"score_gpt":0.3037475857438062,"score_spread":0.2842479758284238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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