{"id":"W3209503376","doi":"10.1016/j.leukres.2021.106735","title":"RUNX1 mutations correlate with response to venetoclax combination therapies in relapsed/refractory acute myeloid leukemia","year":2021,"lang":"en","type":"letter","venue":"Leukemia Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto; Princess Margaret Cancer Centre; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Venetoclax; Myeloid leukemia; Medicine; Refractory (planetary science); Myeloid; Oncology; Leukemia; Cancer research; Internal medicine; Biology; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.005903747,0.001162673,0.001870439,0.005211424,0.0006798292,0.0004636051,0.00152231,0.00300791,0.0007914444],"category_scores_gemma":[0.00252817,0.001051922,0.0003781363,0.00611896,0.001146055,0.0003441814,0.0008886092,0.0218845,0.001626328],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.06091841,"about_ca_system_score_gemma":0.04221647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002194897,"about_ca_topic_score_gemma":0.0003412908,"domain_scores_codex":[0.9829174,0.004281534,0.001382243,0.002488875,0.005661562,0.003268372],"domain_scores_gemma":[0.9881785,0.004959297,0.0002379913,0.003027023,0.002785168,0.0008120065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01467307,0.0001758974,0.0007086737,0.0007202681,0.001104499,0.04585569,0.004257351,0.0005531408,0.01978978,0.00007754599,0.9085767,0.003507401],"study_design_scores_gemma":[0.01687756,0.005647009,0.02192922,0.003741301,0.0003298539,0.001626218,0.001784072,0.002160128,0.00267949,0.0003958497,0.94105,0.001779297],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6057605,0.001148971,0.00007992688,0.3827676,0.0004011747,0.00490616,0.0001892694,0.0002836234,0.004462718],"genre_scores_gemma":[0.295983,0.003159374,0.005878705,0.357621,0.005907565,0.007773433,0.01004977,0.002352475,0.3112747],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.3097776,"threshold_uncertainty_score":0.9991931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04014037466090893,"score_gpt":0.3415210087808559,"score_spread":0.301380634119947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}