{"id":"W3209503376","doi":"10.1016/j.leukres.2021.106735","title":"RUNX1 mutations correlate with response to venetoclax combination therapies in relapsed/refractory acute myeloid leukemia","year":2021,"lang":"en","type":"letter","venue":"Leukemia Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto; Princess Margaret Cancer Centre; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Venetoclax; Myeloid leukemia; Medicine; Refractory (planetary science); Myeloid; Oncology; Leukemia; Cancer research; Internal medicine; Biology; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006013305,0.0001979247,0.0005946083,0.0005974803,0.0006460475,0.000800651,0.0004504585,0.002461755,0.002246221],"category_scores_gemma":[0.003997139,0.0001851149,0.0002950854,0.0007480301,0.0004556353,0.0004182415,0.0002094183,0.00189417,0.0006908571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001345582,"about_ca_system_score_gemma":0.0007862771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002319887,"about_ca_topic_score_gemma":0.006398368,"domain_scores_codex":[0.9995773,0.000105449,0.00005113809,0.00004999743,0.0001216535,0.00009443439],"domain_scores_gemma":[0.9981533,0.0009737554,0.0002555537,0.00008444678,0.0001886709,0.000344218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00420011,0.0005846786,0.5117878,0.0001986838,0.0001623359,0.07719387,0.0006501459,0.0008132142,0.01166808,0.003089999,0.2381452,0.151506],"study_design_scores_gemma":[0.001066305,0.002247965,0.6002324,0.0003578431,0.0003997107,0.1807683,0.001513164,0.006818559,0.006263479,0.008785028,0.1914206,0.0001265832],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6689608,0.01074618,0.0005007797,0.2719357,0.003996326,0.00007193119,0.001239627,0.0001694598,0.04237926],"genre_scores_gemma":[0.9354615,0.002889227,0.000813632,0.04521945,0.005784517,0.00004546539,0.0005843002,0.00004486274,0.009157014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002461755,"threshold_uncertainty_score":0.009763002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04014037466090893,"score_gpt":0.3415210087808559,"score_spread":0.301380634119947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}