{"id":"W3209596180","doi":"10.1186/s13195-021-00919-z","title":"Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Ministry of Science and ICT, South Korea; National Center for Advancing Translational Sciences; Seoul National University; U.S. National Library of Medicine; National Institute on Aging; National Research Foundation; Canadian Institutes of Health Research; National Institute for Health and Care Research; National Research Foundation of Korea; Seoul National University Bundang Hospital","keywords":"Expression quantitative trait loci; Quantitative trait locus; Biology; Genome-wide association study; Transcriptome; Genetic association; Gene; Gene expression; Genetics; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003101971,0.0003028746,0.0002723789,0.000815947,0.0002277139,0.000479273,0.0001936074,0.0003327378,0.002154578],"category_scores_gemma":[0.0006949473,0.0001790249,0.0001977433,0.0005011896,0.0002463747,0.0001442695,0.0002526931,0.0004360224,0.0002143855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001996967,"about_ca_system_score_gemma":0.0001085293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047904,"about_ca_topic_score_gemma":0.0008131194,"domain_scores_codex":[0.9998299,0.00002676462,0.00001360922,0.00007483652,0.00003434834,0.0000205269],"domain_scores_gemma":[0.9995871,0.00009922451,0.0001968612,0.00003558465,0.0000377027,0.00004359315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003893568,0.0001364994,0.5213168,0.0001462994,0.0004275092,0.0007087751,0.0003197527,0.0003700543,0.4572147,0.0002155239,0.0005726743,0.01467782],"study_design_scores_gemma":[0.00002879869,0.00008732996,0.9852288,0.000009056339,0.0001104011,0.0007613173,0.00006094556,0.0006576335,0.01249991,0.0002522116,0.0002957046,0.0000079736],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980856,0.0003307455,0.0006477982,0.00004418624,0.000004416886,0.000004372132,0.0006310064,0.00002321582,0.0002286484],"genre_scores_gemma":[0.9980109,0.00008763017,0.001038285,0.00005456603,0.000006144307,0.00001043933,0.0004451244,0.00001180764,0.0003349688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002154578,"threshold_uncertainty_score":0.007207811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07727311238879934,"score_gpt":0.3597696888495835,"score_spread":0.2824965764607842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}