{"id":"W3209596191","doi":"10.14309/01.ajg.0000772996.83378.7c","title":"S131 CP101, an Investigational Orally Administered Microbiome Therapeutic, Increases Intestinal Microbiome Diversity and Prevents Recurrent C. difficile Infection: Results From a Randomized, Placebo-Controlled Trial","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University Health Network; University of Toronto; St Joseph's Health Care; Western University; University of Calgary","funders":"","keywords":"Medicine; Microbiome; Placebo; Randomized controlled trial; Internal medicine; Clinical endpoint; Antibiotics; Dosing; Clinical trial; Surrogate endpoint; Bioinformatics; Pathology; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00272023,0.001475313,0.003334637,0.0004754125,0.0003572668,0.001453663,0.001060491,0.003008269,0.01007581],"category_scores_gemma":[0.003527853,0.000661991,0.003165376,0.00061396,0.001564505,0.001362462,0.0004781355,0.002400883,0.0009911427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000671195,"about_ca_system_score_gemma":0.00192706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006513501,"about_ca_topic_score_gemma":0.001244855,"domain_scores_codex":[0.998625,0.000762857,0.0001407183,0.0001978509,0.0001583554,0.0001152553],"domain_scores_gemma":[0.9984219,0.0005405973,0.0004510162,0.0001136668,0.0001696393,0.0003032708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9577518,0.004409058,0.0003842408,0.004029711,0.003032541,0.00004543989,0.00003832843,0.0002520343,0.003562323,0.0001603345,0.001439716,0.02489446],"study_design_scores_gemma":[0.9457909,0.05003956,0.001195355,0.0001925804,0.001245069,0.00003635466,0.00001659589,0.0002212707,0.0004325483,0.00008557815,0.0007277759,0.00001656488],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9405855,0.03253242,0.002131902,0.00274608,0.001829284,0.009331668,0.00437658,0.0004958529,0.00597077],"genre_scores_gemma":[0.9691058,0.01128216,0.003937214,0.002489848,0.0008895618,0.006540144,0.002336523,0.00004218656,0.003376483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01007581,"threshold_uncertainty_score":0.03370696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03189707204548881,"score_gpt":0.2962342955130375,"score_spread":0.2643372234675487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}