{"id":"W3209637874","doi":"10.14309/01.ajg.0000776300.15953.f6","title":"S692 Efficacy and Safety of Upadacitinib Induction Therapy in Patients With Moderately to Severely Active Ulcerative Colitis: Results From the Phase 3 U-ACHIEVE Study","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Ulcerative colitis; Gastroenterology; Randomization; Placebo; Clinical trial; Adverse effect; Phases of clinical research; Randomized controlled trial; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001351827,0.0004190473,0.001438296,0.0001536945,0.0002794493,0.0006089639,0.0002654972,0.0005929989,0.004038908],"category_scores_gemma":[0.0008899706,0.0001804143,0.001010323,0.0003326388,0.0002759089,0.0003514001,0.0002476889,0.00121912,0.0005453564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002904509,"about_ca_system_score_gemma":0.0006756712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003564012,"about_ca_topic_score_gemma":0.001188092,"domain_scores_codex":[0.9994685,0.0002708369,0.00004894236,0.00005855835,0.00008356128,0.00006962976],"domain_scores_gemma":[0.9994897,0.0001283973,0.0001603801,0.0000352051,0.00005425017,0.0001321086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7902521,0.008988811,0.01324754,0.002260878,0.002483287,0.000261942,0.000147894,0.001167276,0.023166,0.0002320023,0.007003605,0.1507887],"study_design_scores_gemma":[0.4814281,0.4047072,0.08747637,0.0003572787,0.003784342,0.0008046206,0.0001063018,0.001474863,0.007482232,0.0003433899,0.01195715,0.00007823161],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828723,0.009377438,0.0004530461,0.000581043,0.0001238447,0.000768739,0.00237278,0.0000755548,0.003375203],"genre_scores_gemma":[0.9936458,0.001806637,0.000446284,0.0005832638,0.0001424855,0.0004160721,0.001948277,0.00000986616,0.001001451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004038908,"threshold_uncertainty_score":0.01351148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009302707628605767,"score_gpt":0.2560027728356642,"score_spread":0.2467000652070584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}