{"id":"W3209686187","doi":"10.1016/j.chom.2021.10.001","title":"Mice with diverse microbial exposure histories as a model for preclinical vaccine testing","year":2021,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Canada Foundation for Innovation; U.S. Department of Health and Human Services","keywords":"Immunogenicity; Vaccination; Immunology; Biology; Immune system; Immunity; Influenza vaccine; Humoral immunity; Specific-pathogen-free; Virology; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002519306,0.0002889067,0.0005401648,0.00007701378,0.0003142479,0.0000418261,0.0001592983,0.0001494645,0.00008484883],"category_scores_gemma":[0.001199412,0.0002439498,0.0001530245,0.0002798099,0.0001387752,0.00010175,0.0002809371,0.0003995705,0.00007233216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002281542,"about_ca_system_score_gemma":0.0008720817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007280669,"about_ca_topic_score_gemma":0.0001084945,"domain_scores_codex":[0.9981199,0.0000465019,0.000395193,0.0005974639,0.0002411212,0.0005998262],"domain_scores_gemma":[0.9976638,0.0004308221,0.0001235217,0.000437808,0.001145772,0.0001982818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001987812,0.0004587116,0.006994965,0.0006537778,0.000162602,0.0002258013,0.002279275,0.0000959046,0.9645272,0.00002098175,0.02192436,0.0006685358],"study_design_scores_gemma":[0.02113722,0.002837993,0.002078477,0.0007489314,0.0009683859,0.0004194726,0.002072887,0.002908708,0.7543987,0.00006119641,0.2113453,0.001022693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855699,0.005792883,0.001084597,0.001332071,0.0002539088,0.001281374,0.0001743743,0.000155764,0.004355146],"genre_scores_gemma":[0.7905135,0.0003134159,0.1239871,0.004903218,0.0009414379,0.0002125968,0.0001821081,0.0002030095,0.07874366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2101286,"threshold_uncertainty_score":0.9947986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09757600658366276,"score_gpt":0.3566430464236843,"score_spread":0.2590670398400216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}