{"id":"W3209686187","doi":"10.1016/j.chom.2021.10.001","title":"Mice with diverse microbial exposure histories as a model for preclinical vaccine testing","year":2021,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Canada Foundation for Innovation; U.S. Department of Health and Human Services","keywords":"Immunogenicity; Vaccination; Immunology; Biology; Immune system; Immunity; Influenza vaccine; Humoral immunity; Specific-pathogen-free; Virology; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001363576,0.001954736,0.0008140252,0.002400053,0.001018218,0.0009529255,0.0008805999,0.001842598,0.004089264],"category_scores_gemma":[0.0004561511,0.0004946686,0.0009963424,0.0006303816,0.00115267,0.001361266,0.0006121714,0.004988093,0.001112376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005574246,"about_ca_system_score_gemma":0.000569137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000569353,"about_ca_topic_score_gemma":0.001281533,"domain_scores_codex":[0.9989113,0.0002111958,0.00008360219,0.0002814997,0.0001633681,0.0003490684],"domain_scores_gemma":[0.9990124,0.0001862574,0.0002152855,0.0001799716,0.00008595907,0.0003200472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006950848,0.008715012,0.001670929,0.0001226093,0.00006833038,0.0003603892,0.0002601963,0.0006958442,0.9729897,0.001663422,0.0007269817,0.005775753],"study_design_scores_gemma":[0.0007740292,0.03819572,0.005571722,0.00007421819,0.0002452853,0.001020047,0.0003516302,0.001812527,0.9414274,0.001013663,0.009445343,0.00006833631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775,0.001371887,0.0109882,0.0005862007,0.0003892348,0.001120699,0.003980747,0.0003639836,0.003699088],"genre_scores_gemma":[0.9432365,0.002182456,0.02561806,0.001150884,0.0002116289,0.003634933,0.004385445,0.0003224082,0.01925774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004089264,"threshold_uncertainty_score":0.01367998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09757600658366276,"score_gpt":0.3566430464236843,"score_spread":0.2590670398400216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}