{"id":"W3209720264","doi":"10.32920/ryerson.14649699.v1","title":"mTOR controls lysosome function by modulating the Rab7 GTPase","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"PI3K/AKT/mTOR pathway; Lysosome; Autophagy; Cell biology; mTORC1; Small GTPase; GTPase; RPTOR; Mechanistic target of rapamycin; Guanine nucleotide exchange factor; Activator (genetics); Biology; mTORC2; Chemistry; Signal transduction; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175398,0.0003969301,0.000340438,0.0003050638,0.0002670054,0.000523935,0.0002263234,0.0003110948,0.001223349],"category_scores_gemma":[0.0001043839,0.0001423209,0.0003242256,0.0001582837,0.0002500384,0.0002677775,0.0002855267,0.0004163172,0.0007449857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003108928,"about_ca_system_score_gemma":0.0002162861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004555451,"about_ca_topic_score_gemma":0.0006595131,"domain_scores_codex":[0.999803,0.00003071553,0.00002956223,0.00004368965,0.00004940074,0.00004373067],"domain_scores_gemma":[0.9999347,0.000008959872,0.00002190669,0.000006437442,0.00001221705,0.00001580561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001730513,0.00003037491,0.0002344767,0.00008190627,0.00001053612,0.00007867638,0.00001164045,0.00009085378,0.9959039,0.0002429264,0.0001066161,0.003034998],"study_design_scores_gemma":[0.00001240639,0.0001384481,0.003715684,0.00001016734,0.00002247975,0.0002263728,0.00002584397,0.0009172721,0.9903503,0.00008186983,0.004492398,0.000006805451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780332,0.01052773,0.003283216,0.0003813263,0.00009501097,0.00004653534,0.0008829714,0.0003165199,0.006433597],"genre_scores_gemma":[0.9908952,0.004267327,0.001658691,0.0001037505,0.00002759737,0.00003765474,0.0005627605,0.00003764537,0.002409406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223349,"threshold_uncertainty_score":0.004092515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00848973388916065,"score_gpt":0.2122798555351728,"score_spread":0.2037901216460121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}