{"id":"W3209735640","doi":"10.1016/j.immuni.2021.11.001","title":"Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses","year":2021,"lang":"en","type":"article","venue":"Immunity","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":723,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Icahn School of Medicine at Mount Sinai; National Cancer Institute; University of Pennsylvania; Children's Hospital of Philadelphia","keywords":"Adjuvant; Germinal center; Immune system; Biology; Cytokine; B cell; Vaccination; Lipid A; Immunology; Cell; Virology; Antibody; Lipopolysaccharide; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002034454,0.0005190602,0.0002538249,0.0001868233,0.0001192439,0.0002700669,0.0001022962,0.0004725005,0.001181015],"category_scores_gemma":[0.0001847449,0.0001381272,0.0001858208,0.00005915267,0.0002098467,0.0003130256,0.0002595235,0.0005763642,0.0003958277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002486254,"about_ca_system_score_gemma":0.0002172058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002884615,"about_ca_topic_score_gemma":0.0004748876,"domain_scores_codex":[0.9998391,0.00002975416,0.000009175697,0.00002814508,0.00004485723,0.0000490234],"domain_scores_gemma":[0.9999123,0.00002287332,0.00001867845,0.000007210697,0.00002207528,0.00001690837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001339516,0.00005795463,0.00006215461,0.00004123158,0.000004333965,0.0000197886,0.00001188867,0.0001372939,0.9961715,0.00008294416,0.00008747985,0.003189574],"study_design_scores_gemma":[0.0000503001,0.00108322,0.0008095593,0.000009124155,0.00002328817,0.00009168471,0.00002422432,0.001219585,0.9938454,0.00009798527,0.0027407,0.000004794013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845741,0.001620104,0.00923485,0.0002957543,0.0001469468,0.0001010118,0.0001104723,0.0001711701,0.003745644],"genre_scores_gemma":[0.9925724,0.0005786926,0.003105239,0.000150921,0.00003474786,0.00004611797,0.000132591,0.00002946642,0.003349756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181015,"threshold_uncertainty_score":0.003950834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03750722467550109,"score_gpt":0.3198544123938142,"score_spread":0.2823471877183131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}