{"id":"W3209759134","doi":"10.14309/01.ajg.0000776616.76910.14","title":"S771 Efficacy and Safety of Upadacitinib as Induction Therapy in Patients With Moderately to Severely Active Ulcerative Colitis: Results From Phase 3 U-ACCOMPLISH Study","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Placebo; Ulcerative colitis; Population; Gastroenterology; Randomized controlled trial; Adverse effect; Clinical trial; Surrogate endpoint; Phases of clinical research; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001346486,0.0005660051,0.001734359,0.0002043444,0.0003045688,0.0007781513,0.0004778413,0.0006718155,0.004506322],"category_scores_gemma":[0.001075512,0.0001975224,0.001142693,0.0004048813,0.0004186667,0.0004018139,0.000342814,0.001395802,0.0007215814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000445019,"about_ca_system_score_gemma":0.001021138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005183208,"about_ca_topic_score_gemma":0.001353108,"domain_scores_codex":[0.9995851,0.0001984663,0.0000349624,0.00004741143,0.0000673734,0.00006683233],"domain_scores_gemma":[0.9994475,0.0001253048,0.0001414271,0.00004992956,0.00006214344,0.0001736074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7429264,0.01560592,0.00987794,0.002585984,0.002392867,0.000295078,0.0001871939,0.001678268,0.02823185,0.0002539791,0.007158538,0.188806],"study_design_scores_gemma":[0.5464129,0.3835318,0.04384088,0.0002965612,0.002977724,0.0005801374,0.0001166885,0.001539142,0.009150731,0.0002523305,0.01123251,0.00006857808],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828157,0.008981485,0.0005174776,0.0006272165,0.0001056774,0.001223889,0.001912703,0.0001022828,0.003713659],"genre_scores_gemma":[0.9903592,0.002694701,0.000832476,0.0006922341,0.0001564965,0.0008663756,0.002766949,0.00001769885,0.001613819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004506322,"threshold_uncertainty_score":0.01507515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009510181463306637,"score_gpt":0.2636774203256905,"score_spread":0.2541672388623838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}