{"id":"W3209759595","doi":"10.1242/jcs.258907","title":"Evolutionary conservation of systemic and reversible amyloid aggregation","year":2021,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Simon Fraser University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Amyloid (mycology); Drosophila melanogaster; Model organism; Protein aggregation; Organism; Conserved sequence; Saccharomyces cerevisiae; Cell biology; Genetics; Gene; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005534389,0.0002145649,0.0002156943,0.0006062707,0.0005311934,0.0004688824,0.0002700483,0.0004522007,0.001288645],"category_scores_gemma":[0.0005184861,0.0001351213,0.0001380582,0.0004543566,0.0006024603,0.0003554137,0.0005377688,0.0004935236,0.0002107546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296461,"about_ca_system_score_gemma":0.0001670373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005317483,"about_ca_topic_score_gemma":0.001133309,"domain_scores_codex":[0.9996551,0.00009315676,0.00002124085,0.0001367301,0.00004871632,0.00004508669],"domain_scores_gemma":[0.999725,0.00007206422,0.00007020291,0.00004667179,0.00004711498,0.00003897459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007065662,0.0001482726,0.08021925,0.0002445974,0.0002282307,0.002864438,0.002816703,0.001094722,0.7789783,0.01073912,0.0006409524,0.1213188],"study_design_scores_gemma":[0.00006748262,0.0009274114,0.8853793,0.00009591543,0.000188259,0.01469502,0.001674524,0.003437077,0.04307954,0.006698864,0.0436386,0.0001181433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902037,0.001070333,0.003584893,0.0001887627,0.00001310029,0.00001702863,0.0001070237,0.00002840711,0.004786787],"genre_scores_gemma":[0.9949008,0.0009065021,0.002486924,0.0001322337,0.00001684376,0.0000129006,0.0001999942,0.00002170849,0.001322077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288645,"threshold_uncertainty_score":0.004310966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02136669524707577,"score_gpt":0.2907951767182801,"score_spread":0.2694284814712044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}