{"id":"W3209822455","doi":"10.1136/bmj-2021-068060","title":"Inhaled and intranasal ciclesonide for the treatment of covid-19 in adult outpatients: CONTAIN phase II randomised controlled trial","year":2021,"lang":"en","type":"article","venue":"BMJ","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Health Sciences Centre; University of British Columbia; McGill University Health Centre","funders":"McGill University Health Centre; Covis Pharma; McGill University; GlaxoSmithKline","keywords":"Medicine; Ciclesonide; Placebo; Interquartile range; Confidence interval; Population; Randomized controlled trial; Inhaler; Internal medicine; Physical therapy; Pediatrics; Anesthesia; Asthma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003377217,0.0001135783,0.0003347213,0.00001627124,0.00006972945,0.000007973514,0.00005621403,0.00008981418,0.00003724791],"category_scores_gemma":[0.001226998,0.00006934187,0.0001541829,0.0000414997,0.00004325201,0.000001662268,0.00002381722,0.00002747619,2.017514e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002908851,"about_ca_system_score_gemma":0.000154094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002055404,"about_ca_topic_score_gemma":0.00007319271,"domain_scores_codex":[0.9990866,0.0001875323,0.0002936543,0.0002071354,0.00007043161,0.0001546369],"domain_scores_gemma":[0.9992614,0.0003532291,0.00010311,0.0001184694,0.00006948122,0.00009425868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5736057,0.00139627,0.00001397991,0.00001706642,0.0001874247,0.00001635627,0.0001436509,0.00003070459,0.4156016,0.0001107515,0.0009475272,0.007928988],"study_design_scores_gemma":[0.7687012,0.006808883,0.000004498829,0.000004401397,0.00007925329,0.000003105131,0.0001084902,0.0007020496,0.214999,0.00007541908,0.008436336,0.00007738336],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912708,0.0007125132,0.001943076,0.001242586,0.0002150907,0.00453771,0.00003662625,0.000004061123,0.00003753256],"genre_scores_gemma":[0.9961266,0.0006994681,0.0001648051,0.0009626947,0.0001753248,0.001674126,0.00005591931,0.000007304707,0.0001337646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2006026,"threshold_uncertainty_score":0.282768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374057479648086,"score_gpt":0.3546050271583548,"score_spread":0.330864452361874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}