{"id":"W3209903665","doi":"10.1101/2021.10.25.465799","title":"Nelfinavir induces cytotoxicity towards high-grade serous ovarian cancer cells, involving induction of the unfolded protein response, modulation of protein synthesis, DNA damage, lysosomal impairment, and potentiation of toxicity caused by proteasome inhibition","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Takeda Oncology; Faculty of Medicine and Health, University of Sydney; McGill University; Rivkin Center for Ovarian Cancer","keywords":"Unfolded protein response; Cancer research; DNA damage; Programmed cell death; Pharmacology; Cisplatin; Toxicity; Biology; Chemistry; Apoptosis; Medicine; Internal medicine; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053494,0.0002234871,0.0001923916,0.0001457803,0.0001104281,0.000151249,0.00008299956,0.0001836281,0.0008597607],"category_scores_gemma":[0.00009863641,0.00006758387,0.0001897704,0.0001118176,0.0001100924,0.0001053116,0.0001032907,0.000234093,0.0001194233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000120122,"about_ca_system_score_gemma":0.00009015608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003139761,"about_ca_topic_score_gemma":0.0004639987,"domain_scores_codex":[0.9998984,0.00002762676,0.00001544554,0.00001279735,0.00002232128,0.00002333334],"domain_scores_gemma":[0.9999398,0.0000150941,0.00001190823,0.00001233439,0.000008861791,0.00001199698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003463803,0.00009305406,0.0007191319,0.00006662735,0.000009693116,0.00006491284,0.00002004888,0.0000543641,0.996217,0.00003699967,0.00004273461,0.00232908],"study_design_scores_gemma":[0.00003174743,0.001681433,0.0144372,0.000007273933,0.00001413564,0.0005101388,0.00003710992,0.0005147141,0.9811219,0.0000283163,0.001612684,0.000003411988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971103,0.001488192,0.0004535103,0.00002451441,0.00002034707,0.00001715781,0.0001961355,0.00001799296,0.0006719267],"genre_scores_gemma":[0.9980602,0.0004929476,0.0004062145,0.00001876748,0.000006660821,0.00001517887,0.0003218712,0.000002566768,0.000675642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008597607,"threshold_uncertainty_score":0.002876222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290215708396706,"score_gpt":0.2224645567616158,"score_spread":0.2095623996776488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}