{"id":"W3209952409","doi":"10.1101/2021.10.25.465491","title":"Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Canadian Institutes of Health Research; BC Children's Hospital","keywords":"Mitochondrion; Biology; Cell biology; TFAM; Mitochondrial DNA; Decompensation; Endocrinology; Internal medicine; Mitochondrial biogenesis; Gene; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001240402,0.0002464174,0.0002089554,0.0001148521,0.0001305975,0.0004319168,0.0001877822,0.0002178622,0.001845894],"category_scores_gemma":[0.0001126085,0.0001102086,0.000123907,0.0001078078,0.0002607706,0.0003246809,0.0002979269,0.0005573661,0.0003763911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908334,"about_ca_system_score_gemma":0.0001487539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002140579,"about_ca_topic_score_gemma":0.0002771061,"domain_scores_codex":[0.9998703,0.00001545315,0.00001759088,0.00003271821,0.00002590187,0.00003805611],"domain_scores_gemma":[0.9997247,0.00003737287,0.00009157964,0.00003679661,0.0000239221,0.000085694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001812717,0.00003138804,0.0001985864,0.00001788585,0.000002490522,0.00002479435,0.00001139751,0.00001691126,0.9988715,0.00006083634,0.00002434485,0.0005585579],"study_design_scores_gemma":[0.00003238847,0.0004650557,0.003937551,0.000009596619,0.00001431467,0.00023731,0.00007586821,0.0005079902,0.9927124,0.00007355236,0.001929961,0.000003961706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957544,0.0007482001,0.002268538,0.0001172129,0.00002439242,0.00001068911,0.0002199931,0.00009926206,0.000757464],"genre_scores_gemma":[0.9976109,0.0002741645,0.0005299718,0.00006574465,0.000008209656,0.00001409963,0.0002706893,0.00002178964,0.00120434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001845894,"threshold_uncertainty_score":0.00617516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251727484418327,"score_gpt":0.2309896402188798,"score_spread":0.2058168917770471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}