{"id":"W3209981175","doi":"10.1101/2021.10.29.21265617","title":"Circular RNA detection identifies <i>circPSEN1</i> alterations in brain specific to Autosomal Dominant Alzheimer Disease","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Drug Discovery Foundation; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute on Aging; Alzheimer's Association; Hope Center for Neurological Disorders; Fleni; Japan Agency for Medical Research and Development; Fondation Brain Canada; Korea Health Industry Development Institute; U.S. Department of Defense","keywords":"PSEN1; Circular RNA; Gene; Biology; Genetics; RNA; Computational biology; Alzheimer's disease; Medicine; Disease; Pathology; Presenilin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006700481,0.0006017178,0.0004895927,0.001124007,0.0006121148,0.0008961748,0.0002962739,0.0005184821,0.006196512],"category_scores_gemma":[0.001379203,0.0002976859,0.0005940215,0.0005771366,0.0003901614,0.0003064823,0.0005376337,0.0006641504,0.001972934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003092139,"about_ca_system_score_gemma":0.0002944598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001307149,"about_ca_topic_score_gemma":0.003136949,"domain_scores_codex":[0.9994181,0.00003657133,0.00003216822,0.0003103628,0.0001350717,0.0000677252],"domain_scores_gemma":[0.99938,0.0002275444,0.0001626185,0.00006503727,0.0001094636,0.00005533361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001234155,0.00006281975,0.06435093,0.001220478,0.0003586221,0.000692568,0.000336163,0.001135693,0.889911,0.0009837071,0.005702386,0.03401143],"study_design_scores_gemma":[0.0001224642,0.000480213,0.52486,0.0003789876,0.0007738421,0.005253601,0.0004404336,0.01564574,0.3999111,0.004474994,0.04750476,0.0001539639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.907188,0.006000018,0.03844204,0.0004203859,0.0002390338,0.0001150689,0.03836294,0.003175537,0.006056973],"genre_scores_gemma":[0.9081274,0.001553212,0.04945963,0.000769005,0.000109353,0.000273078,0.03346111,0.00167375,0.004573555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006196512,"threshold_uncertainty_score":0.02072936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776365863904303,"score_gpt":0.2696006574060195,"score_spread":0.2518369987669764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}