{"id":"W3210002151","doi":"10.1038/s41467-021-26614-z","title":"Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":285,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Weill Cornell Medical College; Memorial Sloan-Kettering Cancer Center; Pershing Square Foundation; Debra and Leon Black Family Foundation; Harry J. Lloyd Charitable Trust; Canadian Institutes of Health Research; Melanoma Research Alliance; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Pershing Square Sohn Cancer Research Alliance","keywords":"Cilium; Tumor microenvironment; Transcriptome; Zebrafish; Biology; Cell biology; Computational biology; Melanoma; Cell; Cancer; Gene; Gene expression; Cancer research; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678477,0.0001287094,0.0001274552,0.0000125202,0.0002330359,0.00002018941,0.001422386,0.0001821031,0.0000105295],"category_scores_gemma":[0.0001183679,0.00008390072,0.0001797947,0.0001332533,0.0003025702,0.00000207256,0.0003456489,0.0006962734,0.000001394189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001723112,"about_ca_system_score_gemma":0.00009446034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001265844,"about_ca_topic_score_gemma":0.0009918682,"domain_scores_codex":[0.9990061,0.0002876704,0.0002450134,0.0001919233,0.000128236,0.0001410685],"domain_scores_gemma":[0.9973916,0.0000558615,0.0001054012,0.002326241,0.00008964381,0.00003128882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002772352,0.0001146253,0.001647225,0.0000103728,0.00005668241,2.654542e-7,0.0002538075,0.000173077,0.9948993,0.0004682952,0.001608966,0.0007397081],"study_design_scores_gemma":[0.0003381414,0.00004048632,0.005837707,0.00004342335,0.00005943231,0.00002333606,0.0001247621,0.00006468304,0.6511958,0.0002355192,0.341899,0.0001376408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9297969,0.03861526,0.005013747,0.02254679,0.0005855004,0.000587676,0.0002360147,0.0000191006,0.002598983],"genre_scores_gemma":[0.993608,0.001148704,0.002973425,0.001704235,0.00005529757,0.00001518606,0.00008946125,0.00002003987,0.0003856387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3437034,"threshold_uncertainty_score":0.3421372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278264667347634,"score_gpt":0.247632960188292,"score_spread":0.2348503135148157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}